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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Adlen-4 Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer, and Endometrial cancer. It contains Lenvatinib, an anticancer medication that works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. This medicine is known to cause embryo-fetal toxicity, so it is not recommended for use in pregnancy and breastfeeding.

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Whats That

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Composition :

LENVATINIB-4MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Adlen-4 Capsule

Adlen-4 Capsule is an anti-cancer medicine used in the treatment of various types of cancers. Cancer is a disease caused by the abnormal growth of cells that divide uncontrollably. This medicine is used in treating hepatocellular carcinoma as a first-line therapy, differentiated thyroid cancer in patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory, advanced renal cell carcinoma in combination with pembrolizumab, and advanced endometrial cancer in combination with pembrolizumab.

Adlen-4 Capsule contains Lenvatinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Adlen-4 Capsule may cause certain side effects such as diarrhoea, decreased appetite, nausea, vomiting, tiredness, itching, rash, headache, cough, abdominal pain, hoarseness, and dizziness. Inform your doctor if any of these side effects bother you. Adlen-4 Capsule should be taken as prescribed by your doctor. Do not take more than the recommended dose of medicine.

If you are allergic to Adlen-4 Capsule or its components, inform your doctor. Before taking Adlen-4 Capsule , inform your doctor if you have/had liver or kidney disease, calcium deficiency, heart problems, increased blood pressure, seizures, bleeding disorders, vision problems, and a history of blood clots. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy and breastfeeding.

Uses of Adlen-4 Capsule

Adlen-4 Capsule is used in the treatment of Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer and Endometrial cancer. The detailed uses of Adlen-4 Capsule are as follows:<br/>• Thyroid cancer: Adlen-4 Capsule is used for treatment of specifically differentiated thyroid cancer.<br/>• Kidney cancer (renal cell carcinoma): Adlen-4 Capsule is often used in combination with everolimus when other treatments have failed.<br/>• Endometrial cancer: Adlen-4 Capsule is used with pembrolizumab for advanced or recurrent cases that can’t be treated with surgery or radiation.<br/>• Liver cancer (hepatocellular carcinoma): Adlen-4 Capsule is used for the treatment of liver cancer.<br/>

Directions for Use

• Adlen-4 Capsule can be taken with or without food.• Take Adlen-4 Capsule once daily; however, follow your doctor's advice regarding the dosage and duration.• Swallow Adlen-4 Capsule as a whole with a glass of water.• Do not crush, chew, open or split it.

Medicinal Benefits

Adlen-4 Capsule contains Lenvatinib, which is used in treating different types of cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Adlen-4 Capsule stops the body's production, spread and growth of cancerous cells.

How Adlen-4 Capsule Works

Adlen-4 Capsule contains Lenvatinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Adlen-4 Capsule out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Adlen-4 Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Adlen-4 Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

To treat your condition effectually, continue taking Adlen-4 Capsule for the period that your doctor has prescribed. Avoid taking Adlen-4 Capsule if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Adlen-4 Capsule may cause hypertension, thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes, kidney impairment, hypocalcemia, wound healing problems, and osteonecrosis in some patients. Hence, inform your doctor about your complete medication and medical history before taking Adlen-4 Capsule .

Drug-Drug Interactions

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LenvatinibGrepafloxacin
Critical
LenvatinibMesoridazine
Critical

Drug-Drug Interactions

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LenvatinibGrepafloxacin
Critical
How does the drug interact with Adlen-4 Capsule:
Coadministration of grepafloxacin and Adlen-4 Capsule can increase the risk irregular heart rhythm.

How to manage the interaction:
Although using Adlen-4 Capsule and Grepafloxacin together is not recommended as it can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
LenvatinibMesoridazine
Critical
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule with Mesoridazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Adlen-4 Capsule and mesoridazine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LenvatinibSaquinavir
Critical
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Adlen-4 Capsule and Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and Ziprasidone together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Adlen-4 Capsule and Ziprasidone together is not recomended as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibHalofantrine
Critical
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and Halofantrine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Adlen-4 Capsule and Halofantrine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and Thioridazine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Adlen-4 Capsule and Thioridazine is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and Sparfloxacin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Adlen-4 Capsule and Sparfloxacin is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Adlen-4 Capsule:
Coadministration of Adlen-4 Capsule with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although using Adlen-4 Capsule and Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibAnagrelide
Severe
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule with Anagrelide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Adlen-4 Capsule with Anagrelide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience severe or prolonged diarrhea or vomiting, sudden dizziness or lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Adlen-4 Capsule:
Taking Adlen-4 Capsule and disopyramide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Adlen-4 Capsule with disopyramide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath, severe or long-lasting diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Consult your doctor

It is unknown whether Adlen-4 Capsule interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Adlen-4 Capsule is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Adlen-4 Capsule . You should not become pregnant while you are taking Adlen-4 Capsule for at least 3o days from the last dose of Adlen-4 Capsule . Using effective birth control methods while on treatment with Adlen-4 Capsule is suggested.

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Breast Feeding

Unsafe

Inform your doctor if you are intending to breastfeed. Breastfeeding should be avoided while getting Adlen-4 Capsule and for one week from the final dosage of administration.

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Driving

Unsafe

Adlen-4 Capsule is known to cause dizziness and visual disturbances. Hence, avoid driving and operating machines until you are completely alert.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Notify your doctor if you notice any of the following symptoms: yellowing of your skin or whites of your eyes, fleeing drowsy, abdominal pain, dark-coloured urine, easier bleeding or bruising than usual. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Adlen-4 Capsule . It may cause kidney injury. Notify your doctor if you experience symptoms such as decreased urine output, blood in your urine, ankle edema, or lack of appetite.

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Children

Unsafe

Adlen-4 Capsule is not recommended for use in children, as the safety and efficacy have not been established.

Have a query?

FAQs

Adlen-4 Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer and Endometrial cancer.

Adlen-4 Capsule contains Lenvatinib, which works by inhibiting the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

It is advised not to miss any dose of medicine. If you miss it, take the medicine as soon as you remember. However, if it is time for your next dose, avoid taking the missed dose and do not double the dose.

Country of origin

India

Manufacturer/Marketer address

SCO 84, Sector 5, Panchkula (Haryana) 134112 INDIA.
Other Info - ADL0034

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