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compositionComposition:PERAMPANEL-4MG
prescription
Prescription Medicine
info
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Addperam 4 Tablet is used to treat epilepsy. It contains Perampanel, which works by blocking glutamate receptors in the brain, thereby suppressing the abnormal and excessive activity of the nerve cells. In some cases, this medicine may cause side effects such as dizziness, drowsiness, increased or decreased appetite, weight gain, fatigue, and nausea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PERAMPANEL-4MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Addperam 4 Tablet

Addperam 4 Tablet is a prescription medication used to treat certain types of seizures in people with epilepsy. It is approved for use to help control partial-onset seizures (seizures that start in one part of the brain, with or without spreading to other areas) and primary generalised tonic-clonic seizures (widespread, convulsive seizures). By helping to stabilise the electrical activity in the brain, this medicine aims to reduce the frequency and severity of these episodes.

To achieve the best results, you must take Addperam 4 Tablet consistently every day, exactly as prescribed by your doctor. It is typically taken once daily, usually at bedtime, and can be taken with or without food. Maintaining a regular sleep schedule, avoiding triggers, and eating balanced meals can also support your treatment and improve overall seizure control.

While taking this medication, some people may experience side effects like drowsiness, dizziness, or irritability. It is vital to contact your doctor immediately if you experience severe mood changes, feelings of intense anger, aggression, or thoughts of self-harm, as these require prompt medical evaluation.

Before starting Addperam 4 Tablet , talk to your doctor if you have a history of liver problems, kidney issues, or mental health conditions such as depression or anxiety. Do not take this if you have had a severe allergic reaction to this medication or any of its inactive ingredients in the past.

This medicine can interact with alcohol, which can significantly increase drowsiness and affect your physical coordination. It may also interact with other prescription drugs, making them less effective or increasing side effects. Pregnant women, those planning to breastfeed, and elderly individuals should consult their doctor before taking Addperam 4 Tablet to ensure it is safe for their specific situation.

Uses of Addperam 4 Tablet

Addperam 4 Tablet is used to treat certain types of seizures in people with epilepsy. The detailed uses of Addperam 4 Tablet are as follows:

  • Partial-onset seizures: Addperam 4 Tablet helps reduce the frequency of seizures that begin in a localised area of the brain, whether or not the seizure activity later spreads to other parts of the brain.
  • Primary generalised tonic-clonic seizures: Addperam 4 Tablet helps control major convulsive seizures that affect the entire brain from the very beginning of the episode.

Key Benefits

Addperam 4 Tablet helps control seizures by stabilising abnormal electrical activity in the brain. With regular use as prescribed, it reduces seizure frequency, supports daily safety, and improves overall quality of life.

  • Reduces Seizure Frequency: By controlling abnormal electrical signals in the brain, this medicine helps reduce the frequency of seizures, allowing for a more stable and predictable daily routine.
  • Supports Better Daily Functioning: Fewer seizures help reduce the risk of seizure-related injuries and allow you to participate in everyday activities with greater confidence and independence.
  • Promotes Long-Term Seizure Control: By calming overactive nerve activity in the brain, this medicine helps provide consistent seizure management, offering reassurance and improving overall quality of life.
Side effects of Addperam 4 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Addperam 4 Tablet can be taken with or without food.
  • It is usually taken once daily at bedtime or as prescribed by your doctor.
  • Swallow the whole Addperam 4 Tablet with a glass of water.
  • Do not crush, chew, or break it.

How Addperam 4 Tablet Works

Inside the brain, nerve cells communicate using chemical messengers. One of these chemicals is called glutamate, which acts as an 'on switch' for nerve signals. When glutamate binds to specific docking sites known as AMPA receptors, it excites the nerve cells. If these cells become overactive, it can trigger a sudden storm of electrical activity, resulting in a seizure. Addperam 4 Tablet contains perampanel, which works by selectively blocking these AMPA receptors. By stopping glutamate from attaching to these sites, the medicine calms down overactive nerve signals and prevents the abnormal electrical storms before they start. This targeted action helps maintain a healthy, stable balance of electrical activity in your brain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Addperam 4 Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Addperam 4 Tablet is not recommended during pregnancy.

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Breast Feeding

Caution

It is not known if Addperam 4 Tablet passes into breast milk. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Unsafe

Addperam 4 Tablet causes drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Addperam 4 Tablet if you have a liver impairment or any concerns regarding this. Avoid taking Addperam 4 Tablet if you have serious liver problems.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Addperam 4 Tablet if you have kidney impairment or any concerns regarding this. Avoid taking Addperam 4 Tablet if you have moderate or serious kidney problems.

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Children

Caution

Addperam 4 Tablet is not recommended for children below four years. The safety and effectiveness have not been established in children below 4 years of age for partial seizures and below 7 years of age for generalised seizures.

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Heart

Caution

Addperam 4 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Addperam 4 Tablet .

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Geriatrics

Caution

Addperam 4 Tablet should be given with caution to elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Addperam 4 Tablet

If you take more than your prescribed dose of Addperam 4 Tablet , seek immediate medical attention. Symptoms of an overdose may include extreme sleepiness, severe confusion, difficulty walking, or sudden, severe behavioural changes.

Diet & Lifestyle Advise

  • Prioritise consistent sleep: Lack of sleep is a common trigger for seizures. Aim for 7 to 9 hours of restful sleep every night and stick to a regular bedtime routine.
  • Avoid alcohol entirely: Alcohol can trigger seizures and dangerously multiply the sedative effects of Addperam 4 Tablet , leading to severe drowsiness and confusion.
  • Keep a detailed seizure diary: Record the date, time, and details of any seizures, along with your daily sleep quality and stress levels. This helps your doctor monitor how well your medication is working.
  • Practice daily stress management: High stress levels can lower your seizure threshold. Incorporate gentle activities like deep breathing, meditation, or quiet walks into your daily routine.
  • Avoid extreme dieting: Sudden changes in your eating habits or blood sugar levels can trigger seizures. Eat balanced meals at regular intervals throughout the day.
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How Soon It Starts Working

The time required for Addperam 4 Tablet to start to work: The exact onset time of Addperam 4 Tablet has not been clinically established. The time for which the effects of Addperam 4 Tablet last: The duration of Addperam 4 Tablet ’s effect is clinically not established.

What if you forget to take Addperam 4 Tablet

If you miss a dose of Addperam 4 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. If you miss doses for more than a few days in a row, talk to your doctor or pharmacist before taking your next dose.

Storage

• Store Addperam 4 Tablet tablets and oral suspension at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Monitor your behaviour daily: Ask a trusted family member or roommate to help watch for sudden changes in your personality, anger, mood swings, or aggression.
  • Do not drive or operate machinery: Avoid driving, riding a bicycle, or handling hazardous equipment until you know exactly how this medicine affects your alertness and balance.
  • Avoid sudden discontinuation: Never stop taking Addperam 4 Tablet on your own. Doing so can cause continuous, life-threatening seizures that are difficult to stop.
  • Measure liquid doses carefully: If using the oral suspension, write the date of opening on the bottle. Safely discard any unused liquid suspension after the number of days specified by the manufacturer (usually 90 days after opening).
  • Take it at bedtime: Taking your dose right before bed can help you sleep through the peak drowsiness and dizziness side effects, reducing your risk of daytime falls.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain other anti-seizure medications: Drugs like carbamazepine, phenytoin, or oxcarbazepine can speed up how your body processes Addperam 4 Tablet , which may lower its levels in your blood and make it less effective.
  • Hormonal contraceptives: Addperam 4 Tablet can reduce the effectiveness of birth control pills containing estrogen, increasing the risk of an unplanned pregnancy. Talk to your doctor about using reliable non-hormonal birth control.
  • Central Nervous System (CNS) depressants: Taking this medicine alongside sleep aids, muscle relaxants, or anxiety medications can cause extreme drowsiness and slow breathing.
PerampanelBuprenorphine
Severe
PerampanelEsketamine
Severe

Drug-Drug Interactions

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PerampanelBuprenorphine
Severe
How does the drug interact with Addperam 4 Tablet:
When buprenorphine is used with Addperam 4 Tablet, it may lead to significant adverse effects.

How to manage the interaction:
Concomitant administration of buprenorphine alongside Addperam 4 Tablet can result in an interaction, it can be taken if a doctor has advised it. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Consult a doctor if you have any questions or concerns. Do not discontinue any medications without consulting a doctor.
PerampanelEsketamine
Severe
How does the drug interact with Addperam 4 Tablet:
Co-administration of Addperam 4 Tablet with esketamine can increase the risk of side effects of Addperam 4 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Addperam 4 Tablet and Esketamine, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PerampanelKetamine
Severe
How does the drug interact with Addperam 4 Tablet:
Using ketamine together with Addperam 4 Tablet may increase side effects such as dizziness, drowsiness, confusion and difficulty concentrating.

How to manage the interaction:
Although there is a possible interaction between Addperam 4 Tablet and Ketamine, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PerampanelSodium oxybate
Severe
How does the drug interact with Addperam 4 Tablet:
Using sodium oxybate together with Addperam 4 Tablet may increase side effects such as dizziness, drowsiness, confusion, difficulty concentrating

How to manage the interaction:
Although taking Addperam 4 Tablet and Sodium oxybate together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol completely while taking this medication. Alcohol significantly increases the risk of severe drowsiness, confusion, and loss of physical coordination.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Addperam 4 Tablet is used to treat epilepsy/seizures.
Addperam 4 Tablet prevents seizures by blocking a receptor in the brain known as the glutamate receptor, thereby suppressing the abnormal and excessive activity of the nerve cells in the brain.
Yes. Addperam 4 Tablet may reduce the effectiveness of certain hormonal contraceptives, including some birth control pills containing levonorgestrel or estrogen. Use an effective non-hormonal contraceptive method, such as condoms or a copper intrauterine device (IUD), during treatment and discuss the most appropriate contraception with your doctor.
Addperam 4 Tablet may cause weight gain, so try to maintain a proper weight by following a healthy diet and exercising regularly.
Addperam 4 Tablet has a potential for abuse and dependence. It is a controlled substance, and long-term use can lead to physical dependence and withdrawal symptoms when stopped.
When taking Addperam 4 Tablet , it's important to be aware of the potential side effects. While rare, these can include suicidal thoughts and behavior, severe allergic reactions, and serious psychiatric events like aggression, agitation, and hallucinations. Additionally, Addperam 4 Tablet may increase the risk of seizures, especially in people with a history of seizure disorders. However, by being mindful of these possibilities and working closely with your healthcare team, you can minimize risks and maximize the benefits of this medication.
When stopping Addperam 4 Tablet , withdrawal symptoms may occur. These can include insomnia (difficulty sleeping), nausea, headache, dizziness, irritability, anxiety, agitation, aggressive behavior, hallucinations, confusion, and seizures (in people with a history of seizure disorders). If you're considering stopping Addperam 4 Tablet , it's essential to consult your doctor for guidance and support to manage the process and ensure your safety.
While taking Addperam 4 Tablet , avoiding certain activities and substances is crucial to ensure your safety. Avoid driving or operating heavy machinery, as Addperam 4 Tablet can cause drowsiness and sedation. Also, avoid consuming alcohol and other central nervous system depressants, as they can worsen these effects. Additionally, avoid stopping the medication suddenly, as this can lead to withdrawal symptoms. Following your doctor's guidance and advice is vital while taking Addperam 4 Tablet .
No. Do not stop taking Addperam 4 Tablet without consulting your doctor, even if your seizures have stopped or you feel well. Stopping the medicine suddenly may cause withdrawal symptoms or increase the risk of seizures. If treatment needs to be stopped, your doctor will gradually reduce your dose to lower these risks.
The common side effects of Addperam 4 Tablet may include blurred or double vision, constipation, decreased sense of touch or sensation, dizziness or a sense of spinning, drowsiness, headache, irritability, muscle, back, or joint pain, nausea, problems with coordination, tiredness, vomiting, and weight gain.
Epilepsy is a neurological disorder that affects the central nervous system and is characterized by recurrent seizures due to abnormal electrical activity in the brain. These seizures can disrupt consciousness, movement, sensation, or other bodily functions. Possible causes of epilepsy include high fever, trauma, genetic disorders, brain injury, or stroke.
Sudden changes in behaviour, hostility, and aggression are serious risks associated with this medicine. If you or your family members notice these changes, contact your doctor immediately. Do not wait for your next scheduled appointment.
Addperam 4 Tablet is generally not recommended during pregnancy. If you are pregnant, planning to become pregnant, or planning to conceive, talk to your doctor before taking this medicine. Use effective contraception during treatment and for one month after your last dose, or as advised by your doctor. Your doctor will weigh the benefits of seizure control against the potential risks to your baby.
Addperam 4 Tablet can cause severe drowsiness, dizziness, and double vision, especially when you first start taking it or when your doctor is gradually increasing your dose. You should not drive or operate machinery until you are certain the medicine does not affect your ability to do so safely. Talk to your doctor for personalised advice.

Disclaimer

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Reference

  1. U.S. Food and Drug Administration (FDA). 202834S011Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Perampanel Perampanel. 2018. [Accessed on 17 Jun. 2019]Check here
  4. Perampanel Perampanel. [Accessed on 12 Feb. 2026]Check here
  5. Fycompa 2 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) - 4276 [Internet]. Medicines.org.uk. 2023 [Accessed on 2025 Mar 25]Check here
  6. Fycompa 2 mg film-coated tablets - Patient Information Leaflet (PIL) - (emc) - 4276 [Internet]. Medicines.org.uk. 2023 [Accessed on 2025 Mar 25]Check here
  7. Eisai Manufacturing Limited. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 21st May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - ADD0107

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