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compositionComposition:CORTICOTROPIN-60IU
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Prescription Medicine
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Acton Prolongatum 60 Iu/ml Injection 5 ml is indicated for the treatment of infantile spasms in infants and children under two years of age. It can also be indicated for the treatment of exacerbations of multiple sclerosis in adults. Besides this, it is used to treat various chronic inflammatory or autoimmune conditions, including rheumatic, collagen disorders, dermatologic, allergic conditions, ophthalmic, respiratory, and oedema. Acton Prolongatum 60 Iu/ml Injection 5 ml contains Corticotropin, a natural form of adrenocorticotropic hormone (ACTH). It interacts with melanocortin receptors and may affect cell activity relating to your condition. It also works with the body’s immune system to help reduce inflammation associated with certain chronic inflammatory or autoimmune diseases.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CORTICOTROPIN-60IU

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Acton Prolongatum 60 Iu/ml Injection 5 ml

Acton Prolongatum 60 Iu/ml Injection 5 ml is an injectable medicine used to treat certain conditions involving severe inflammation or an overactive immune response. It is also used to treat infantile spasms, a specific type of seizure that occurs in babies, and acute flare-ups of multiple sclerosis (MS) in adults.

This medicine is given as an injection under the skin or into a muscle. Depending on the product and condition being treated, you or a caregiver may be taught how to give the injections at home.

Acton Prolongatum 60 Iu/ml Injection 5 ml affects natural steroid hormones produced by your body. Treatment may reduce your body's own production of these hormones, especially with higher doses or longer treatment. For this reason, do not stop treatment suddenly unless your doctor tells you to do so. Your dose may need to be reduced gradually.

Side effects can include increased appetite, weight gain, fluid retention, trouble sleeping, mood changes, and stomach upset. The medicine can also increase blood pressure and blood sugar, lower potassium levels, and make it harder for your body to fight infections.

Before starting treatment, tell your doctor if you have diabetes, high blood pressure, heart problems, kidney problems, stomach ulcers, eye problems, an infection, or any other medical condition. Also tell your doctor about all medicines and vaccines you receive and if you are pregnant or breastfeeding.

Children receiving this medicine require careful medical supervision. The dose and treatment duration depend on the child's age, weight, condition, and response. In babies with infantile spasms, treatment usually follows a specific short-term schedule prescribed and closely monitored by a specialist.

Uses of Acton Prolongatum 60 Iu/ml Injection 5 ml

Your doctor may prescribe Acton Prolongatum 60 Iu/ml Injection 5 ml to help manage the following conditions:

  • Infantile spasms: Helps control a specific type of seizure that usually begins during infancy.
  • Multiple sclerosis flare-ups: Helps reduce inflammation during sudden worsening of MS symptoms and may help speed recovery from a flare.
  • Certain rheumatic and joint conditions: Helps reduce severe inflammation associated with conditions such as rheumatoid arthritis when appropriate.
  • Severe allergic conditions: Helps control severe allergic inflammation when other treatments are not suitable or have not worked adequately.
  • Certain inflammatory eye and skin conditions: Helps reduce severe inflammation affecting the eyes or skin when prescribed for an appropriate condition.

Key Benefits

Acton Prolongatum 60 Iu/ml Injection 5 ml can help control severe inflammation and excessive immune activity when these are causing significant symptoms.

  • Reduces inflammation: Helps decrease swelling, pain, redness, and other symptoms caused by severe inflammation.
  • Helps control infantile spasms: Can reduce or stop spasms in some babies, helping manage a serious seizure disorder that requires prompt treatment.
  • Supports recovery from MS flare-ups: May shorten the duration of symptoms during an acute MS flare, helping patients recover more quickly.
  • Helps manage severe inflammatory conditions: May provide symptom control when other treatments are not appropriate or have not provided enough relief.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Acton Prolongatum 60 Iu/ml Injection 5 ml can be self-administered or given by a relative or friend after proper training.
  • Read the manufacturer’s instructions and get training from your doctor or a nurse on injection technique.

How Acton Prolongatum 60 Iu/ml Injection 5 ml Works

Acton Prolongatum 60 Iu/ml Injection 5 ml contains corticotropin, which acts like a natural hormone in the body called adrenocorticotropic hormone (ACTH). ACTH is a signal hormone released by the brain that tells the adrenal glands, which are small glands above the kidneys, to make cortisol. Cortisol is a natural steroid hormone that helps control inflammation and the activity of the immune system. By increasing the body's production of cortisol, this medicine can help reduce excessive inflammation and immune activity. Corticotropin may also act directly on certain cells in the body. These actions may contribute to its treatment effects. The exact way it helps control infantile spasms is not fully understood.
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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Acton Prolongatum 60 Iu/ml Injection 5 ml. However, as a precautionary measure, it is advisable to avoid or limit alcohol consumption.

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Pregnancy

Caution

It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. So, inform your doctor before receiving Acton Prolongatum 60 Iu/ml Injection 5 ml if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known whether this drug is excreted in human milk. When treating a nursing mother with Acton Prolongatum 60 Iu/ml Injection 5 ml, a decision should be made whether to discontinue nursing or to discontinue the drug, considering the risk and benefit to the mother. You should not breastfeed unless the doctor advises.

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Driving

Caution

Acton Prolongatum 60 Iu/ml Injection 5 ml may cause physical weakness and Convulsions; it may impact on your ability to drive or operate machinery; therefore, do not drive or operate machinery.

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Liver

Caution

If you have liver problems, inform your doctor before taking Acton Prolongatum 60 Iu/ml Injection 5 ml. Your doctor will weigh the benefits and potential risks before prescribing Acton Prolongatum 60 Iu/ml Injection 5 ml.

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Kidney

Caution

If you have kidney problems, inform your doctor before taking Acton Prolongatum 60 Iu/ml Injection 5 ml. Your doctor will weigh the benefits and potential risks before prescribing Acton Prolongatum 60 Iu/ml Injection 5 ml.

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Children

Safe if prescribed

Your doctor will weigh the benefits and risks before prescribing this medicine for your child.

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Heart

Caution

Acton Prolongatum 60 Iu/ml Injection 5 ml should be used with caution in individuals with heart problems, as it may cause fluid retention, hypertension, and cardiac hypertrophy, especially with prolonged use. If necessary, it must be administered under strict medical supervision with regular monitoring of cardiovascular status.

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Geriatrics

Caution

Acton Prolongatum 60 Iu/ml Injection 5 ml may be used in geriatric patients, but with extra caution due to age-related changes in kidney, liver, and cardiovascular function. Older adults are more susceptible to side effects like fluid retention, hypertension, mood changes, and bone thinning, so close medical supervision and regular monitoring are essential.

What if I have taken an overdose of Acton Prolongatum 60 Iu/ml Injection 5 ml

If more than the prescribed dose is given, seek medical advice promptly. Excessive exposure may increase effects such as high blood pressure, high blood sugar, fluid retention, or electrolyte changes.

Diet & Lifestyle Advise

  • Limit excess salt: Reducing high-salt foods may help manage fluid retention and increased blood pressure.
  • Choose a balanced diet: Include appropriate sources of protein, calcium, vitamin D, and other nutrients, particularly during longer treatment courses.
  • Discuss potassium intake: Corticotropin can lower potassium levels. Your doctor may recommend dietary changes or supplements if your potassium becomes low.
  • Reduce infection exposure: Wash your hands regularly and avoid close contact with people who have contagious infections when possible.
  • Monitor blood sugar if advised: This medicine can raise blood sugar, particularly in people with diabetes.
  • Follow activity advice: Regular appropriate activity can support bone and muscle health, but follow your doctor's recommendations for your condition.

Health Queries

Is Acton Prolongatum 60 IU/ml Injection safe to use for a 2‑month‑old baby?

Bayyarapu Mahesh Kumar

Bayyarapu Mahesh Kumar

M Pharmacy

Acton Prolongatum 60 IU/ml Injection is a powerful prescription hormone medicine (ACTH) used mainly for serious conditions such as infantile spasms. It is not safe to use on your own for a 2‑month‑old baby. This injection must be prescribed and administered only by a specialist doctor in a hospital setting, because the dose, indication, and monitoring are highly critical in infants. If you have any concerns about your baby’s health, please consult a paediatrician immediately for proper evaluation and treatment advice.
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Have a query?

How Soon It Starts Working

The time required for Acton Prolongatum 60 Iu/ml Injection 5 ml to start to work: Acton Prolongatum 60 Iu/ml Injection 5 ml ideally shows its action within few minutes after administration. The time for which the effects of Acton Prolongatum 60 Iu/ml Injection 5 ml last: The effect of Acton Prolongatum 60 Iu/ml Injection 5 ml lasts for 10 to 25 hours.

What if you forget to take Acton Prolongatum 60 Iu/ml Injection 5 ml

If you miss a scheduled dose, contact your doctor or pharmacist for instructions. The correct action can depend on your treatment schedule and condition. Do not give two doses together unless your doctor specifically tells you to do so.

Storage

•Store Acton Prolongatum 60 Iu/ml Injection 5 ml according to the temperature and storage instructions provided with your product label, typically between 20°C and 25°C.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Attend regular monitoring: Your doctor may check your blood pressure, blood sugar, potassium and other electrolyte levels during treatment. Other blood tests may also be needed depending on your condition and treatment duration.
  • Have your eyes checked when advised: Corticotropin can increase the risk of eye problems such as raised pressure inside the eye or cataracts, particularly with longer treatment. Your doctor may recommend eye examinations.
  • Do not stop suddenly: Treatment can temporarily reduce your body's natural cortisol production. Your doctor may gradually reduce your dose to allow your body time to restore normal hormone production.
  • Watch for infection: Consult your doctor right away if you develop fever, chills, persistent sore throat, or other signs of infection.
  • Monitor children carefully: Children may need monitoring of blood pressure, blood sugar, growth, weight, and signs of infection during treatment.
  • Tell your doctor about vaccines: Some vaccines, particularly live vaccines, may not be appropriate while your immune response is suppressed. Check with your doctor before receiving any vaccine.
  • Report vision changes: Consult your doctor if you develop blurred vision, eye pain, or other changes in eyesight.
  • Carry medical information: During or after significant treatment, carry information showing that you are receiving or recently received corticotropin, particularly if your doctor recommends it.

Drug-Drug Interactions

verifiedApollotooltip
  • Diuretics (e.g. furosemide, hydrochlorothiazide): These medicines can add to the potassium-lowering effect of corticotropin, increasing the risk of low potassium levels.
  • Corticosteroids (e.g. prednisolone, dexamethasone): Using these medicines together may increase steroid-related effects such as high blood sugar, fluid retention, high blood pressure, or increased infection risk.
  • NSAID pain medicines (e.g. ibuprofen, naproxen): These medicines may increase the risk of stomach irritation, ulcers, or bleeding when used during treatment.
  • Diabetes medicines (e.g. insulin, metformin): Corticotropin can raise blood sugar, so diabetes treatment may need adjustment.
  • Vaccines: The immune response to vaccines may be reduced during treatment. Live vaccines may pose additional risks when the immune system is significantly suppressed.
CorticotropinBaricitinib
Severe
CorticotropinLeflunomide
Severe

Drug-Drug Interactions

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CorticotropinBaricitinib
Severe
How does the drug interact with Acton Prolongatum 60 Iu/ml Injection 5 ml:
Coadministration of Acton Prolongatum 60 Iu/ml Injection 5 ml with Baricitinibcan increases the risk of developing serious infections.

How to manage the interaction:
Co-administration of Baricitinib with Acton Prolongatum 60 Iu/ml Injection 5 ml can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CorticotropinLeflunomide
Severe
How does the drug interact with Acton Prolongatum 60 Iu/ml Injection 5 ml:
Combining Acton Prolongatum 60 Iu/ml Injection 5 ml with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Although taking Leflunomide and Acton Prolongatum 60 Iu/ml Injection 5 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not stop using any medications without talking to your doctor.
CorticotropinClozapine
Severe
How does the drug interact with Acton Prolongatum 60 Iu/ml Injection 5 ml:
When Clozapine is taken with Acton Prolongatum 60 Iu/ml Injection 5 ml, can increase the effect of Clozapine.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Acton Prolongatum 60 Iu/ml Injection 5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Acton Prolongatum 60 Iu/ml Injection 5 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Acton Prolongatum 60 Iu/ml Injection 5 ml is used to treat Infantile spasms, Multiple sclerosis, Inflammatory or autoimmune conditions.
Acton Prolongatum 60 Iu/ml Injection 5 ml contains Corticotropin, a natural form of adrenocorticotropic hormone (ACTH). It interacts with melanocortin receptors and may affect cell activity relating to your condition. Aside from that, it works with the body's immune system to help reduce inflammation associated with some chronic inflammatory or autoimmune disorders.
Acton Prolongatum 60 Iu/ml Injection 5 ml may cause behavioural and mood changes. People taking Acton Prolongatum 60 Iu/ml Injection 5 ml should be closely monitored for their behaviour. Speak with your doctor immediately if you need to.
Common adverse reactions for Acton Prolongatum 60 Iu/ml Injection 5 ml are fluid retention, alteration in glucose tolerance (Glucose levels are higher during the evening compared with morning), elevation in blood pressure, behavioural and mood changes, increased appetite and weight gain.
No. This medicine can temporarily reduce your body's natural production of cortisol, an important hormone that helps your body respond to stress. Your doctor may gradually reduce your dose before stopping treatment so your body has time to restore normal cortisol production.
Depending on the prescribed product and treatment plan, you or a caregiver may be able to give the injections at home after receiving proper training from a healthcare professional.
Your doctor may check your blood pressure, blood sugar, potassium and other blood levels. Eye examinations may also be recommended, especially with longer treatment. Children may require additional monitoring of growth and development.
Some vaccines may not be suitable while this medicine is affecting your immune system. Check with your doctor before receiving any vaccine, particularly a live vaccine.
Longer or repeated treatment can affect growth in children. Your child's doctor may monitor height, weight, and development during treatment.
Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Your doctor will assess the potential benefits and risks and decide whether treatment is appropriate.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 022432S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A613006 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Corticotropin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. What is Acthar® Gel (repository corticotropin injection)?. [Accessed on 02 Jun. 2026]Check here
  5. Purified Cortrophin® Gel (repository corticotropin injection USP). [Accessed on 02 Jun. 2026]Check here
  6. Repository Corticotropin Injection (Acthar Gel and Purified Cortrophin Gel). [Accessed on 02 Jun. 2026]Check here
  7. Search Results. [Accessed on 02 Jun. 2026]Check here

Country of origin

INDIA

Manufacturer/Marketer address

K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA
Other Info - ACT0019

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