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compositionComposition:ALTEPLASE-50MG
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Prescription Medicine
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₹45849 with coupons & bank offers*

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Actilyse 50 mg Injection is used to prevent the formation of harmful blood clots in your blood vessels. Thus, it helps to reduce the risk of Acute Ischemic Stroke (AIS) and Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure. On the other hand, it can treat acute massive pulmonary embolism (PE) in the lysis. It works by dissolving blood clots that block blood flow to the affected tissue.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALTEPLASE-50MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Actilyse 50 mg Injection

Actilyse 50 mg Injection is a specialised injectable medicine used to dissolve dangerous blood clots that have formed in the blood vessels. It is primarily prescribed during medical emergencies such as acute ischemic strokes, heart attacks, and massive blood clots in the lungs. By quickly breaking down these blockages, this treatment helps restore normal blood flow to vital organs like the brain, heart, and lungs.

Because Actilyse 50 mg Injection is an emergency medication, it is typically given as a single, rapid treatment session in a hospital setting rather than on a regular daily schedule. While you do not need to prepare for this medication with food or dietary restrictions, long-term lifestyle changes are highly beneficial after recovery. Adopting a heart-healthy diet, managing your blood pressure, and staying active under medical supervision can significantly reduce the risk of future blood clots.

The most common side effects associated with Actilyse 50 mg Injection involve bleeding, such as bruising or bleeding at the injection site. However, because this medicine powerfully thins the blood, there is a risk of more serious internal bleeding. You must seek immediate medical attention if you experience severe headaches, blood in your urine or stool, or sudden weakness after receiving this treatment.

Before receiving Actilyse 50 mg Injection, it is vital to inform the medical team of your complete health history. Actilyse 50 mg Injection should not be used in people with active internal bleeding, recent brain surgery or significant head injury, severe uncontrolled high blood pressure, certain bleeding disorders, or bleeding inside the brain. Other medical conditions, such as recent major surgery or recent bleeding, may require your doctor to carefully weigh the benefits and risks before treatment.

This medicine can interact heavily with other blood thinners, aspirin, and certain blood pressure medications, which can drastically increase your risk of bleeding. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits clearly with your doctor, as these groups require special medical monitoring during and after treatment.

Uses of Actilyse 50 mg Injection

Actilyse 50 mg Injection helps dissolve blood clots and restore normal blood flow in emergency situations. Your doctor may prescribe it for the following conditions:

  • Ischemic Stroke: Actilyse 50 mg Injection helps dissolve clots in the blood vessels of the brain, restoring blood flow and reducing the risk of permanent brain damage or disability. For eligible patients, treatment should be started as soon as possible after symptoms begin, as its benefits decrease with time. Your medical team will quickly assess whether treatment is appropriate.
  • Heart Attack (Acute Myocardial Infarction): This medicine dissolves blockages in the coronary arteries, reopening blood flow to the heart muscle and preventing severe muscle damage during a heart attack.
  • Pulmonary Embolism: It is used to clear life-threatening blood clots that have traveled to the lungs, restoring normal breathing and relieving extreme strain on the heart.
  • Blocked Central Venous Catheters: In smaller doses, it helps clear clotted medical tubes or catheters inserted into major veins, restoring their function without requiring surgery.

Key Benefits

Using Actilyse 50 mg Injection as prescribed helps dissolve blood clots quickly and restore blood flow during medical emergencies. Here are the key benefits you can expect:

  • Rapid clot dissolution: Actilyse 50 mg Injection quickly breaks down blood clots, helping restore normal blood flow and improving outcomes in life-threatening emergencies.
  • Reduces long-term complications: When given promptly after a stroke or heart attack, it helps minimise permanent tissue damage and reduces the risk of long-term disability.
  • Supports recovery: By restoring blood flow to affected organs, Actilyse 50 mg Injection improves the chances of recovery and helps preserve normal organ function.
  • Restores catheter function: In patients with blocked central venous catheters, Actilyse 50 mg Injection can clear blood clots without surgery, allowing medicines, fluids, or nutrition to be delivered without interruption.
Side effects of Actilyse 50 mg Injection
  • Your doctor may change or stop your medication to help manage your symptoms.
  • Your doctor may also prescribe medicine to lower stomach acid production or prevent blood flow to an injury.
  • Avoid taking pain relievers like NSAIDs or aspirin, as they can cause bleeding in your stomach.
  • Check with your doctor for safer pain relief options.
  • Do not smoke, as nicotine can make your symptoms worse by damaging blood vessels.
  • Avoid alcohol and caffeine, as they can irritate your stomach.
  • Eat a balanced diet with plenty of fruits, vegetables, lean meats, fish, low-fat dairy, and beans to help your body heal.
  • Drink extra fluids as recommended by your doctor.
  • Avoid massaging the bruise, as this might worsen the damage to the injured tissue.
  • Resting the affected area helps prevent more injury and aids healing.
  • Place a cloth-wrapped ice pack or cold compress on the affected area for 10 to 15 minutes.
  • If the bruise is extensive, severe, or accompanied by other symptoms like warmth, redness, or swelling, get medical help.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Actilyse 50 mg Injection will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Actilyse 50 mg Injection Works

Actilyse 50 mg Injection contains alteplase, a thrombolytic (clot-dissolving) medicine that helps restore blood flow by breaking down blood clots. Alteplase works by mimicking a natural protein in your body that dissolves blood clots. It binds to the clot and activates plasminogen, converting it into plasmin, an enzyme that breaks down fibrin, the protein mesh that holds the clot together. As the fibrin is dissolved, the clot breaks apart, allowing blood to flow normally again to oxygen-deprived tissues and organs.
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Alcohol

Caution

Consuming alcohol along with Actilyse 50 mg Injection is not advisable.

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Pregnancy

Caution

There are no adequate and well-controlled studies on pregnant women. So inform your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe Actilyse 50 mg Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

There is no substantial research yet on using Actilyse 50 mg Injection in breastfeeding/nursing mothers. Let your doctor know if you are a nursing mother before taking Actilyse 50 mg Injection; your doctor will decide whether Actilyse 50 mg Injection can be taken by breastfeeding mothers or not.

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Driving

Not applicable

Actilyse 50 mg Injection has no or negligible influence on the ability to drive or use machines.

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Liver

Safe if prescribed

Inform your doctor before receiving the Actilyse 50 mg Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Safe if prescribed

Inform your doctor before receiving the Actilyse 50 mg Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

The safety and effectiveness of Actilyse 50 mg Injection have not been established in children.

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Heart

Safe if prescribed

Actilyse 50 mg Injection is generally safe for heart patients if prescribed, but should be used under medical supervision.

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Geriatrics

Safe if prescribed

Actilyse 50 mg Injection is generally safe for elderly patients. However, please consult your doctor if you have any concerns.

What if I have taken an overdose of Actilyse 50 mg Injection

An overdose of this medication is managed immediately by hospital staff. Signs of an overdose typically involve severe, uncontrolled bleeding. Doctors will monitor you closely and administer appropriate treatments to help your blood clot if necessary.

Diet & Lifestyle Advise

  • Follow a Heart-Healthy Diet: Eat plenty of vegetables, fruits, whole grains, and lean proteins to support your heart and blood vessel health.
  • Limit Salt and Unhealthy Fats: Reduce your intake of salt, saturated fats, and processed foods to help maintain healthy blood pressure.
  • Avoid Strenuous Activities: Refrain from heavy lifting, high-impact exercise, or other strenuous activities immediately after treatment to reduce the risk of bleeding or bruising.
  • Stay Hydrated: Drink enough fluids to support healthy blood circulation, unless your doctor advises otherwise.
  • Resume Exercise Gradually: Work with your doctor to develop a safe, gradual exercise plan once you have recovered from your medical emergency.

Health Queries

I was in a road accident with head and small intestine injuries. After surgery, my SPO? dropped to 70% one hour after removing the oxygen mask. What could be causing this?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

A sudden drop in oxygen levels (SPO?) after surgery may indicate a lung complication such as pneumonia, fluid in the lungs, or a blood clot. You must seek immediate medical help from hospital staff, as this is a medical emergency requiring urgent oxygen therapy and other treatments.

My potassium and other electrolyte levels are normal, but I am experiencing symptoms that resemble hypokalemia (low potassium), such as leg cramps, confusion, palpitations, chest pain, and fatigue. Could this be a pulmonary embolism or another underlying issue?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Even with normal potassium levels, these symptoms can have many causes, such as heart rhythm problems, medications, dehydration, or, less commonly, a pulmonary embolism (a blood clot in the lung arteries). You should consult your doctor promptly to determine the underlying cause and have your heart and lungs examined.
health query

Have a query?

How Soon It Starts Working

The time required for Actilyse 50 mg Injection to start to work: Actilyse 50 mg Injection ideally shows its action within 20 to 50 minutes after administration. The time for which the effects of Actilyse 50 mg Injection last: The effect of Actilyse 50 mg Injection lasts for 4 hours.

What if you forget to take Actilyse 50 mg Injection

Since this medication is administered as a one-time emergency procedure by medical experts in a clinical setting, missing a dose is not a concern for patients.

Storage

• Unopened vials of Actilyse 50 mg Injection should be stored at room temperature (below 30°C) or refrigerated between 2°C and 8°C, as directed by the manufacturer.

Drug Warnings

  • Hospital Administration Only: Actilyse 50 mg Injection is for hospital use only and must be administered by a trained healthcare professional.
  • Report Recent Medical Events: Tell your healthcare team if you have had any recent surgery, major injury, fall, or bleeding disorder before receiving this medicine.
  • Reduce the Risk of Bleeding: Avoid using traditional razors or hard-bristled toothbrushes immediately after treatment, as they may increase the risk of bleeding.
  • Inspect Before Administration: Your healthcare team will check that the solution is clear, colourless, and free from visible particles before administering it.
  • Avoid Invasive Procedures: Do not undergo dental work or other invasive medical procedures until your doctor confirms it is safe to do so.

Drug-Drug Interactions

verifiedApollotooltip

Blood thinners (such as warfarin or heparin): May greatly increase your risk of severe internal bleeding.

Antiplatelet medications (such as aspirin or clopidogrel): Can enhance the clot-dissolving effect, raising the risk of bleeding.

NSAID pain relievers (such as ibuprofen or naproxen): May increase the risk of stomach bleeding when used close to the time of injection.

AlteplaseHeparin
Critical
AlteplaseDasatinib
Severe

Drug-Drug Interactions

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AlteplaseHeparin
Critical
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with Heparin can increase the risk of bleeding.

How to manage the interaction:
Taking Heparin with Actilyse 50 mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AlteplaseDasatinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Combining Dasatinib with Actilyse 50 mg Injection can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Dasatinib with Actilyse 50 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. During your treatment, it's important to keep a close eye on any bleeding issues. If you notice any of these symptoms - like bleeding, bruising, dizziness, or black stools - make sure to contact your doctor right away. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
AlteplaseCangrelor
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Cangrelor with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Cangrelor and Actilyse 50 mg Injection, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not discontinue any medications without consulting a doctor.
AlteplaseFondaparinux
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Actilyse 50 mg Injection and Fondaparinux, it can be taken if a doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, or weakness contact a doctor right away. Do not stop using any medications without talking to a doctor.
AlteplaseIbrutinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Ibrutinib with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Actilyse 50 mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseRivaroxaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
AlteplaseApixaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Coadministration of Actilyse 50 mg Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Actilyse 50 mg Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AlteplasePrasugrel
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Prasugrel with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Actilyse 50 mg Injection and Prasugrel, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseDabigatran etexilate
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Dabigatran etexilate with Actilyse 50 mg Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Actilyse 50 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Actilyse 50 mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Actilyse 50 mg Injection is used to treat Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure and Acute Massive Pulmonary Embolism (PE).
Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.
The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.
The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose Acute Myocardial Infarction (AMI) puts them at low risk for death or heart failure.
Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered with Alteplase therapy. And also recommended not to take concomitant angiotensin-converting enzyme inhibitors may increase the risk of angioedema.
Actilyse 50 mg Injection is administered by a healthcare professional. Do not self-administer.
Actilyse 50 mg Injection is safe when used as per the dose and duration advised by a doctor.
After taking Actilyse 50 mg Injection, you may not notice an immediate difference. The effects may not be noticeable immediately but it does not mean Actilyse 50 mg Injection is not working. It works by reducing the risk of blood clots in the blood vessels. So, it is important to continue the treatment as prescribed by your doctor.
Actilyse 50 mg Injection causes side effect such as bleeding and injection site reactions. Contact a doctor if these side effects persists for longer durations.
The medicine is cleared quickly from your bloodstream, mostly by your liver, within a few hours after the infusion ends. Talk to your doctor to learn more about how your body processes this medicine.
Inform the medical team immediately of any recent surgeries, injuries, bleeding problems, or if you are pregnant or breastfeeding. Talk to your doctor to ensure all safety checks are completed.
No, it only dissolves existing clots. Your doctor will likely prescribe other long-term medications and lifestyle changes to prevent new clots from forming. Talk to your doctor about your long-term care plan.
Before giving Actilyse 50 mg Injection for a suspected stroke, doctors perform brain imaging to confirm that the stroke is caused by a blood clot rather than bleeding. Actilyse 50 mg Injection should not be used to treat bleeding in the brain because it can make the bleeding worse. Talk to your doctor if you have questions about the tests being performed.
Actilyse 50 mg Injection works best when it is given as soon as possible after stroke symptoms begin. Earlier treatment improves the chance of restoring blood flow and reducing long-term disability. If you notice symptoms such as facial drooping, arm weakness, or difficulty speaking, seek emergency medical care immediately.
After treatment, your healthcare team will closely monitor your blood pressure, neurological condition, and signs of bleeding. You may stay in a specialised stroke unit or intensive care area for observation until your doctor confirms that your condition is stable.

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Country of origin

Germany

Manufacturer/Marketer address

1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Other Info - ACT0010
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