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compositionComposition:BENDAMUSTINE-100MG
prescription
Prescription Medicine
info
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Acodamust Injection is used to treat Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia. Acodamust Injection contains Bendamustine; it works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medication is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BENDAMUSTINE-100MG

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Acodamust Injection

Acodamust Injection is a prescription medication used to treat certain types of blood and lymph cancers, such as chronic lymphocytic leukaemia and indolent B-cell non-Hodgkin lymphoma. It works by targeting and slowing the growth of cancer cells in the body. This medicine is prescribed when other initial treatments may not have worked or when the disease has returned.

Since Acodamust Injection is given as an intravenous infusion in a clinic or hospital, it is scheduled in cycles by your healthcare team. It is crucial to attend all scheduled infusion appointments to maintain a consistent level of the medicine in your body. Because it is given directly into a vein, food intake does not affect how it is absorbed, but staying well-hydrated before and after your sessions is highly recommended to support your kidneys.

Some people may experience common side effects like nausea, extreme tiredness, low blood cell counts, or mild fever. It is very important to contact your doctor immediately if you experience serious symptoms such as signs of a severe infection (like high fever or chills), unusual bruising or bleeding, or breathing difficulties.

Do not take this if you have a known severe allergy to any of its ingredients, or if you have severe liver damage or severe kidney disease. Talk to your doctor before starting Acodamust Injection if you have a history of heart problems, active infections, or liver conditions.

Acodamust Injection can interact with other medications that affect your immune system or liver function, which may increase the risk of severe side effects. It is highly advised to avoid alcohol and smoking during treatment as they can strain your liver and worsen fatigue. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider immediately, as this medicine can harm an unborn baby.

Uses of Acodamust Injection

Acodamust Injection is used to treat certain types of blood and lymph cancers. The detailed uses of Acodamust Injection are as follows:

  • Chronic Lymphocytic Leukaemia: Acodamust Injection helps by destroying abnormal white blood cells that grow too quickly, allowing healthy blood cells to function better.
  • Indolent B-cell Non-Hodgkin Lymphoma: Acodamust Injection targets and slows down the growth of slow-growing cancer cells in the lymphatic system, especially when other treatments have stopped working.

Key Benefits

Acodamust Injection helps treat certain blood and lymph cancers by slowing the growth and spread of cancer cells. When used as prescribed, it helps control disease progression, relieve cancer-related symptoms, and support better long-term treatment outcomes.

  • Helps Control Blood and Lymph Cancers: By targeting rapidly dividing cancer cells, this medicine helps manage conditions such as leukaemia and lymphoma, supporting remission when achievable and slowing disease progression.
  • Relieves Cancer-Related Symptoms: As the number of cancer cells decreases, this medicine may help reduce symptoms such as swollen lymph nodes, night sweats, unexplained weight loss, and fatigue, improving daily comfort and quality of life.
  • Supports Recovery Between Treatment Cycles: Given in planned treatment cycles, this medicine allows healthy cells time to recover between doses, helping support your body's strength and tolerance throughout cancer therapy.
Side effects of Acodamust Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Acodamust Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Acodamust Injection Works

Acodamust Injection contains bendamustine, which belongs to a group of medicines known as alkylating agents. It works by binding directly to the DNA inside rapidly multiplying cancer cells. Once attached, it creates cross-links that damage the DNA structure, preventing the cells from dividing and growing. Because cancer cells divide much faster than most normal cells, they are highly sensitive to this DNA damage. When the DNA is damaged beyond repair, the cancer cells receive a signal to self-destruct. This targeted destruction helps reduce the overall tumour burden in the body.
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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Acodamust Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Acodamust Injection. Use reliable methods of birth control while on treatment with Acodamust Injection.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Acodamust Injection. You should not breastfeed while on treatment with Acodamust Injection.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Acodamust Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Acodamust Injection is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Acodamust Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Acodamust Injection is not recommended for use in children as the safety and efficacy is not established.

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Heart

Caution

Acodamust Injection should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Acodamust Injection.

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Geriatrics

Safe if prescribed

Acodamust Injection is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Acodamust Injection

Because this medication is prepared and given by trained medical professionals in a controlled clinical environment, an accidental overdose is highly unlikely. If an overdose is suspected, medical staff will monitor you closely and provide immediate supportive care. If you feel unwell or suspect an issue after leaving the clinic, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of fluids (such as water or clear broths) before, during, and after your treatment days. This helps your kidneys flush out the waste products of destroyed cancer cells and reduces the risk of kidney complications.
  • Eat Small, Frequent Meals: To help manage nausea, try eating smaller portions of bland foods throughout the day instead of three large meals. Avoid greasy, spicy, or extremely sweet foods.
  • Practice Strict Hygiene: Because Acodamust Injection can temporarily lower your white blood cell count (reducing your body's ability to fight infections), wash your hands frequently. Avoid crowded places and close contact with people who are sick.
  • Protect Your Skin from the Sun: Your skin may become more sensitive during treatment. Apply a broad-spectrum sunscreen, wear protective clothing, and limit your time in direct sunlight.
  • Prioritise Rest: Fatigue is a very common side effect. Listen to your body and schedule regular rest periods throughout the day, while maintaining light activity like walking if your doctor approves.
health query

Have a query?

How Soon It Starts Working

The time required for Acodamust Injection to start to work: The time required for Acodamust Injection to show its action is not clinically established. The time for which the effects of Acodamust Injection last: The duration of action for Acodamust Injection is not clinically established.

What if you forget to take Acodamust Injection

Since Acodamust Injection is given by healthcare professionals on a strict clinical schedule, it is unlikely that you will miss a dose. However, if you miss an appointment or need to reschedule, contact your doctor or clinic immediately to set up a new appointment. Keeping your treatment on schedule is vital for its success.

Storage

• Acodamust Injection is stored and handled exclusively by your clinic, hospital, or pharmacy.

Drug Warnings

  • Inspect the Infusion Site: Inform your nurse immediately if you feel any burning, pain, swelling, or redness near the injection site during or after the infusion.
  • Do Not Get Live Vaccines: Avoid getting live vaccines (such as the shingles, measles, or oral polio vaccines) during treatment, as your weakened immune system may not react safely.
  • Monitor Your Temperature Daily: Keep a reliable thermometer at home and check your temperature if you feel unwell. A fever during chemotherapy is a medical emergency.
  • Use Reliable Contraception: Both men and women should use highly effective birth control during treatment and for several months afterwards to prevent pregnancy, as Acodamust Injection can cause severe birth defects.
  • Prepare for Routine Blood Tests: Expect to have regular blood tests before each treatment cycle to monitor your liver function, kidney health, and blood cell counts.

Drug-Drug Interactions

verifiedApollotooltip
  • CYP1A2 Inhibitors/Inducers: Medicines that affect the liver enzyme CYP1A2 (such as fluvoxamine or ciprofloxacin) can change how your body breaks down Acodamust Injection, potentially increasing side effects or reducing effectiveness.
  • Immunosuppressants: Taking other drugs that weaken the immune system can dangerously increase your risk of severe infections.
BendamustineBaricitinib
Severe
BendamustineCladribine
Severe

Drug-Drug Interactions

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BendamustineBaricitinib
Severe
How does the drug interact with Acodamust Injection:
Combining Acodamust Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Acodamust Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineCladribine
Severe
How does the drug interact with Acodamust Injection:
Combining Cladribine with Acodamust Injection can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Acodamust Injection and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineLeflunomide
Severe
How does the drug interact with Acodamust Injection:
Combining Acodamust Injection with Leflunomide can increase the likelihood of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Acodamust Injection and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms - like an infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
BendamustineInfliximab
Severe
How does the drug interact with Acodamust Injection:
When Acodamust Injection is taken with Infliximab, it can cause the metabolism of Acodamust Injection to speed up. This can increase the risk of developing serious infections.

How to manage the interaction:
Taking Acodamust Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Do not stop using any medications without talking to a doctor.
BendamustineTofacitinib
Severe
How does the drug interact with Acodamust Injection:
Using tofacitinib together with Acodamust Injection may increase the risk of developing serious infections.

How to manage the interaction:
Taking Tofacitinib with Acodamust Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
BendamustineClozapine
Severe
How does the drug interact with Acodamust Injection:
Combining Acodamust Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Acodamust Injection and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately If you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Acodamust Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Hair thinning or mild hair loss can occur while receiving Acodamust Injection, although complete hair loss is less common than with some other chemotherapy medicines. Constipation may also occur in some people. These side effects are usually manageable. Tell your doctor if they become severe, persist, or interfere with your daily activities.
Acodamust Injection is given as an intravenous infusion into a vein by a trained healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about the infusion process.
Some people feel very tired, dizzy, or weak after receiving an infusion of Acodamust Injection. It is best to have someone drive you to and from your appointments until you know how the medicine affects you. Talk to your doctor for personalised advice.
Treatment with Acodamust Injection is given in structured cycles determined by your doctor. A cycle typically lasts a few weeks, with the medicine given on specific days. Talk to your doctor to understand your specific treatment plan.
It is highly recommended to avoid alcohol while taking Acodamust Injection. Alcohol can increase the risk of liver strain and worsen side effects like nausea and fatigue. Talk to your doctor or pharmacist before drinking any alcohol.
Acodamust Injection can lower your white blood cells, red blood cells, and platelets. Regular blood tests are essential to ensure your blood counts recover safely before your next dose. Talk to your doctor about your blood test results.
A fever of 38°C (100.4°F) or higher is a medical emergency when you are receiving Acodamust Injection, as it can indicate a serious infection. Contact your doctor or seek emergency medical care immediately. Talk to your doctor about infection signs.
No, you should not plan to conceive during treatment. Acodamust Injection can cause severe harm to a developing baby. Use highly effective birth control during treatment and for the time period recommended by your healthcare team. Talk to your doctor about safe family planning options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - AC90168
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