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compositionComposition:ACICLOVIR-500MG
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Acivir 500mg Infusion is an antiviral medicine used in the treatment of herpes simplex and varicella-zoster (shingles) infections. This medicine contains aciclovir, which works by inhibiting the herpes simplex virus type 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV), thereby preventing the spread of the infection. Common side effects include nausea, vomiting, loss of appetite, itching, hive-like rash, swelling, and injection site reactions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ACICLOVIR-500MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Acivir 500mg Infusion

Acivir 500mg Infusion is an antiviral medicine injected into a vein to treat severe viral infections. Doctors prescribe it for serious conditions like herpes simplex encephalitis, severe genital herpes, or shingles in individuals with weak immune systems.

This medication is typically given as a slow drip in a hospital or clinic setting, with the frequency and consistency of your treatment determined by your doctor. While receiving this therapy, staying highly hydrated by drinking plenty of water is essential to help protect your kidneys. Making simple lifestyle adjustments, such as getting adequate rest and avoiding physical stress, can also help support your body’s recovery.

Most people tolerate this treatment well, though some may experience mild side effects like redness at the injection site, nausea, or headaches. However, you must inform your healthcare provider immediately if you experience serious symptoms such as confusion, severe dizziness, or a sudden change in how much you urinate.

Talk to your doctor before starting this treatment if you have a history of kidney disease or nervous system disorders. Do not take this if you have had a severe allergic reaction to similar antiviral medications in the past.

Inform your healthcare team about all other medicines you take, especially those that can affect your kidneys, as they can interact with this treatment. It is also vital to tell your doctor if you are pregnant, planning to breastfeed, or are an elderly individual, so your dose can be carefully managed.

Uses of Acivir 500mg Infusion

Your doctor may prescribe Acivir 500mg Infusion to help manage the following conditions:

  • Severe Herpes Simplex infections: Treats severe infections of the skin, mucous membranes, or brain by stopping the virus from multiplying.
  • Neonatal herpes simplex infection: Treats serious herpes simplex infections in newborn babies to help control the infection early and reduce the risk of severe complications affecting the brain, organs, or other parts of the body.
  • Varicella-Zoster (Shingles or Chickenpox): Treats severe shingles or chickenpox in patients with weakened immune systems to prevent the virus from spreading.
  • Prevention of Herpes Simplex: Prevents viral infections in patients with compromised immune systems undergoing specialised medical treatments.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Speeds Recovery from Severe Viral Infections: Acivir 500mg Infusion helps you recover faster from severe viral infections by stopping the virus from spreading within your body.
  • Stops Viral Multiplication: By controlling the replication of the virus, it helps relieve the intense pain, burning, and itching associated with active outbreaks.
  • Reduces the Risk of Serious Complications: Additionally, this medicine significantly lowers the risk of severe complications, such as viral spread to internal organs or brain inflammation, which can be life-threatening.
  • Promotes Healing of Skin Sores: For individuals with weakened immune systems, it provides critical protection and promotes the healing of painful skin sores.
Side effects of Acivir 500 mg Infusion
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Eat foods rich in vitamins C and E, and healthy fats.
  • Consider soft foods like smoothies, soups, and scrambled eggs.
  • Take supplements like vitamins C and E, zinc, and omega-3 fatty acids under medical supervision.
  • Include anti-inflammatory foods like omega-3 rich foods, berries, leafy greens, and spices.
  • Avoid allergens and consider an elimination diet.
  • Practice gentle skin care with non-irritating cleansers and moisturizers.
  • Keep skin well-moisturized with fragrance-free products.
  • Monitor for complications like infection and temperature regulation.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Acivir 500mg Infusion will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Acivir 500mg Infusion Works

Aciclovir is an antiviral medicine that directly targets cells infected by the virus. Once injected into your body, it is converted into an active form that mimics the natural building blocks of the virus's genetic material (DNA). When the virus tries to use this copycat block to replicate and multiply, the replication process is blocked. This successfully stops the virus from spreading, allowing your body's immune system to naturally fight off and clear the infection.
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Alcohol

Caution

It is advised to avoid alcohol consumption while being treated with Acivir 500mg Infusion to enable your body to fight off infections and reduce the worsening of side effects.

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Pregnancy

Caution

Please seek medical advice if you are pregnant or planning to conceive. Your doctor will prescribe Acivir 500mg Infusion only if the benefits outweigh the risk.

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Breast Feeding

Caution

Acivir 500mg Infusion should be administered to a nursing mother cautiously and only when indicated. Please consult your doctor before taking Acivir 500mg Infusion if you are breastfeeding.

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Driving

Caution

If you notice any symptoms affecting your driving ability while being treated with Acivir 500mg Infusion, do not drive or operate machinery. Drive only when you are alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment before starting Acivir 500mg Infusion.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases/impairment before starting Acivir 500mg Infusion. Dose adjustment may be required.

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Children

Caution

Acivir 500mg Infusion should be used for children only when advised by a doctor. The doctor will prescribe the dosage depending on the child's age and weight.

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Heart

Caution

Acivir 500mg Infusion is generally safe for patients with heart problems, but caution is needed. Always consult your doctor to ensure it won’t interact with your heart medications or condition.

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Geriatrics

Caution

Geriatric patients can receive Acivir 500mg Infusion, but extra caution is needed due to age-related kidney decline. Doctors typically adjust the dose and monitor kidney function closely to avoid toxicity.

What if I have taken an overdose of Acivir 500mg Infusion

In the event of an accidental overdose, seek immediate medical attention. An overdose of injected Acivir 500mg Infusion can cause kidney damage, confusion, or seizures, which require urgent medical treatment in a hospital.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Ensure you drink large amounts of water throughout your treatment. This helps your kidneys flush the medicine out safely and prevents kidney strain.
  • Keep viral sores clean and dry: If you are treating skin blisters, keep them clean and dry to prevent secondary bacterial infections.
  • Avoid physical contact during outbreaks: If you are treating active herpes, avoid close physical contact with others to prevent transmitting the virus.
  • Prioritise rest: Give your body ample time to recover by getting plenty of sleep, as a strong immune system is essential for overcoming severe infections.
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Have a query?

How Soon It Starts Working

The time required for Acivir 500mg Infusion to start to work: The onset time of Acivir 500mg Infusion has not been clinically established.

The time for which the effects of Acivir 500mg Infusion last: The duration of Acivir 500mg Infusion’s effect is clinically not established.

What if you forget to take Acivir 500mg Infusion

Since this medicine is injected by a healthcare professional in a clinical setting, missed doses are rare. If you miss an appointment or believe you have missed a dose, contact your clinic or healthcare provider immediately to reschedule.

Storage

•Store Acivir 500mg Infusion vials at room temperature, ideally between 15°C and 25°C.

Drug Warnings

  • Inspect Before Use: Always inspect the solution before use; it should be clear and colourless. Do not inject it if you see particles or if the liquid looks cloudy.
  • Stay Well Hydrated: Stay highly hydrated before, during, and after each infusion to protect your kidneys.
  • Monitor the Injection Site: Monitor your injection site closely and inform your nurse immediately if you feel pain, burning, or notice swelling.
  • Attend Regular Kidney Monitoring: Ensure you undergo scheduled blood tests, as your doctor will need to monitor your kidney function regularly during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Kidney-Damaging Medicines: Medicines that can affect kidney function (such as NSAID pain relievers, certain antibiotics, or other antivirals) may increase the risk of kidney damage when used alongside Acivir 500mg Infusion.
  • Probenecid Interaction: Probenecid, a medication used for gout, can slow down the removal of Acivir 500mg Infusion from your body, potentially increasing the risk of side effects.
AciclovirCidofovir
Critical
AciclovirAmphotericin b
Severe

Drug-Drug Interactions

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AciclovirCidofovir
Critical
How does the drug interact with Acivir 500 mg Infusion:
Co-administration of Cidofovir with Acyclovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Acivir 500 mg Infusion with Cidofovir is not recommended, please consult your doctor before taking it. You should consult a doctor if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, weakness, and palpitations. Do not stop using any medications without talking to a doctor.
AciclovirAmphotericin b
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Acivir 500 mg Infusion with Amphotericin B can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Acivir 500 mg Infusion with Amphotericin b together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirTenofovir alafenamide
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Acivir 500 mg Infusion with Tenofovir alafenamide may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Acivir 500 mg Infusion with tenofovir alafenamide can result in an interaction. However, if the benefits outweigh the risks, your doctor will prescribe them. Contact a doctor immediately if you experience symptoms such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medication without consulting your doctor.
AciclovirEverolimus
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Acivir 500 mg Infusion with Everolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Acivir 500 mg Infusion with Everolimus together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, breathing difficulty, muscle pains, dizziness, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirTenofovir disoproxil
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Acivir 500 mg Infusion with Tenofovir Disoproxil may increase the risk or severity of kidney disorder.

How to manage the interaction:
Coadministration of Acivir 500 mg Infusion with Tenofovir disoproxil can result in an interaction, it can be taken when your doctor has advised it. Contact a doctor immediately if you experience decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AciclovirTizanidine
Severe
How does the drug interact with Acivir 500 mg Infusion:
Concomitant use of Acivir 500 mg Infusion with Tizanidine can increase the risk of developing low blood pressure.

How to manage the interaction:
Coadministration of Acivir 500 mg Infusion with Tizanidine can result in an interaction, but it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, excessive sweating, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirTacrolimus
Severe
How does the drug interact with Acivir 500 mg Infusion:
Co-administration of Acivir 500 mg Infusion with tacrolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Coadministration of Acivir 500 mg Infusion with Tacrolimus can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without first consulting a doctor.
AciclovirIodamide
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Iodamide contrast with Acivir 500 mg Infusion may increase the risk or severity of kidney injury.

How to manage the interaction:
Before undergoing any imaging procedure let your doctor know you are on Acivir 500 mg Infusion treatment.
AciclovirMetrizamide
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Metrizamide in contrast with Acivir 500 mg Infusion may increase the risk or severity of kidney disorder.

How to manage the interaction:
Before undergoing any imaging procedure, let your doctor know you are on Acivir 500 mg Infusion treatment. Look out for signs such as vomiting, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, or weakness. Consult the doctor immediately.
AciclovirSirolimus
Severe
How does the drug interact with Acivir 500 mg Infusion:
Coadministration of Acivir 500 mg Infusion with Sirolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Acivir 500 mg Infusion with Sirolimus can result in an interaction, it can be taken if your doctor has advised it. However, if you experience vomiting, a decrease in hunger, irregular urine, weight gain or loss, swelling, difficulty breathing, muscle pain, or weakness, consult a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Acivir 500mg Infusion when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Acivir 500mg Infusion belongs to the class of 'antivirals' that treat herpes simplex (herpes simplex virus/HSV-1 and HSV-2) infections and varicella-zoster (shingles) infections.
Acivir 500mg Infusion should be used with proper caution and doctor consultation if you have any allergic reactions to medicines, liver or kidney diseases, weakened immune system, breathing problems, or an electrolyte imbalance.
Please consult a doctor before you start Acivir 500mg Infusion if you are undergoing any immunisations/vaccinations, especially vaccines against the varicella virus.
Acivir 500mg Infusion may elevate blood urea and creatinine levels that determine kidney functioning. It may also increase liver enzymes. Hence, seek medical advice before undergoing any laboratory examinations.
No, Acivir 500mg Infusion does not cure the underlying virus. It stops the virus from multiplying, which helps your body fight off the active infection and heal your symptoms. Talk to your doctor for more information.
It is given as a slow injection directly into a vein (intravenous infusion), usually over a period of one hour by a healthcare professional. Talk to your doctor if you have questions about your treatment plan.
This medicine is processed by your kidneys. Drinking plenty of water helps prevent the medicine from forming crystals in your kidneys, protecting them from damage. Talk to your doctor or pharmacist about how much water you should drink.
Some mild soreness is common, but if you experience sudden, severe pain, swelling, or burning at the injection site, tell your healthcare provider immediately. Talk to your doctor if the pain persists.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Acyclovir Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Aciclovir 800 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 11 July 2025]Check here
  4. Aciclovir 800 mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 11 July 2025]Check here
  5. Drugbank.Acyclovir.Drugbank[Accessed on 11July 2025]Check here
  6. Taylor M, Gerriets V. Acyclovir. [Updated 2023 May 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed on 11 July 2025]Check here
  7. CDSCO - Aciclovir [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 11 July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - ACI0298
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