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compositionComposition:ACALABRUTINIB-100MG
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Prescription Medicine
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Acabrunat 100 Capsule is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL). It contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Acabrunat 100 Capsule

Acabrunat 100 Capsule is a prescription medicine used to treat adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). It is also prescribed to treat adults with mantle cell lymphoma (MCL) who have already received at least one other treatment. This targeted medication is designed to help control the growth and spread of cancer cells in the blood and lymph nodes.

To get the best results, you must take Acabrunat 100 Capsule consistently every day, exactly as your doctor prescribes. This medication is typically taken on a daily basis to maintain a steady level of the medicine in your body. You can take this oral capsule with or without food. Incorporating gentle, regular physical activity and eating a balanced, nutrient-dense diet can help support your body's energy levels and immune system during treatment.

While taking Acabrunat 100 Capsule , you may experience common, mild side effects such as headaches, mild diarrhoea, or feeling very tired. However, you must contact your healthcare team immediately if you develop serious symptoms, such as unusual bleeding, severe bruising, high fever, or an irregular heartbeat.

Before starting this medication, talk to your doctor if you have a history of bleeding disorders, heart rhythm problems, or active infections, or if you plan to have any upcoming surgeries. Do not take this medicine if you have ever had a severe allergic reaction to any of its ingredients.

This medicine can interact with blood thinners, certain stomach acid reducers, and other medications, which can either reduce its effectiveness or increase your risk of severe bleeding. It is also important to avoid smoking and limit alcohol consumption, as these habits can put additional stress on your body and worsen side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, you must consult your doctor to discuss specific safety measures before starting treatment.

Uses of Acabrunat 100 Capsule

Acabrunat 100 Capsule is used to treat adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). The detailed uses of Acabrunat 100 Capsule are as follows:

  • Chronic Lymphocytic Leukaemia (CLL) and Small Lymphocytic Lymphoma (SLL): Acabrunat 100 Capsule helps by blocking signals that tell cancer cells to multiply, slowing down the progression of these blood and bone marrow cancers.
  • Mantle Cell Lymphoma (MCL): For patients who have already tried other therapies, Acabrunat 100 Capsule targets specific proteins inside the abnormal B-cells, helping to shrink or control the tumour.
     

Key Benefits

Acabrunat 100 Capsule offers significant clinical benefits by directly targeting cancer cells while sparing many healthy cells, which helps manage the disease with more manageable side effects than traditional chemotherapy. Some of the key benefits patients experience include:

  • Slowing Cancer Progression: By keeping the cancer from spreading, it helps patients maintain their daily activities and enjoy a better quality of life.
  • Convenient Oral Therapy: Because it is taken as an oral capsule, it reduces the need for frequent, lengthy hospital visits for intravenous infusions.
  • Symptom Control: Over time, successfully controlling the leukaemia or lymphoma can reduce symptoms like night sweats, extreme fatigue, and swollen lymph nodes.
Side effects of Acabrunat 100 Capsule
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Acabrunat 100 Capsule can be taken with or without food as advised by your doctor.
  • It is advised to take Acabrunat 100 Capsule twice a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Acabrunat 100 Capsule Works

Acabrunat 100 Capsule contains acalabrutinib, which works as a highly selective Bruton's tyrosine kinase (BTK) inhibitor. BTK is a specific protein inside B-cells (a type of white blood cell) that sends signals telling these cells to grow, survive, and multiply. In cancers like leukaemia and lymphoma, these signals become hyperactive, leading to the uncontrolled growth of abnormal B-cells. By binding directly to the BTK protein, Acabrunat 100 Capsule blocks these growth signals. Without these signals, the cancerous B-cells cannot survive or replicate, which helps to shrink lymph nodes and lower the number of cancer cells in your blood and bone marrow. Because this therapy is targeted, it is designed to minimise damage to other healthy cells in your body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Acabrunat 100 Capsule .

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Pregnancy

Unsafe

Acabrunat 100 Capsule should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Acabrunat 100 Capsule should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Acabrunat 100 Capsule does not influence the ability to drive or use machines. However, go only if you are alert, as the Acabrunat 100 Capsule may cause tiredness in some people.

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Liver

Caution

Avoid using Acabrunat 100 Capsule in patients with severe hepatic impairment. The safety of Acabrunat 100 Capsule has not been evaluated in patients with moderate or severe hepatic impairment. So, caution should be exercised while using Acabrunat 100 Capsule in patients with liver impairment. If you have a pre-existing or a history of liver disease, inform your doctor before taking the Acabrunat 100 Capsule . Your doctor will weigh the benefits and potential risks before prescribing Acabrunat 100 Capsule .

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Kidney

Caution

Caution should be exercised while using Acabrunat 100 Capsule in patients with kidney impairment. If you have a pre-existing or a history of kidney disease, inform your doctor before taking the Acabrunat 100 Capsule . Your doctor will weigh the benefits and potential risks before prescribing Acabrunat 100 Capsule .

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Children

Caution

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Caution

Acabrunat 100 Capsule may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Acabrunat 100 Capsule .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Acabrunat 100 Capsule to geriatric patients. Your doctor will prescribe Acabrunat 100 Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Acabrunat 100 Capsule

If you take too much of this medicine, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit and Seville oranges: These fruits can interact with how your body breaks down Acabrunat 100 Capsule , potentially raising the levels of the medicine in your blood to unsafe levels.
  • Stay well-hydrated: Drink plenty of water throughout the day to support your kidney function and help manage mild side effects like headaches or diarrhoea.
  • Practice strict infection prevention: Because this medicine can lower your white blood cell count, wash your hands frequently, avoid close contact with people who are sick, and ensure all food is thoroughly washed and cooked.
  • Protect your skin from the sun: Some patients taking this class of medicine may have a slightly higher risk of developing skin cancers. Wear protective clothing and apply broad-spectrum sunscreen when outdoors.
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How Soon It Starts Working

The time required for Acabrunat 100 Capsule to start to work: Acabrunat 100 Capsule ideally shows its action within 1 hour after administration. The time for which the effects of Acabrunat 100 Capsule last: The effect of Acabrunat 100 Capsule lasts for 12 hours.

What if you forget to take Acabrunat 100 Capsule

If you miss a dose of Acabrunat 100 Capsule , take it as soon as you remember. However, if your next scheduled dose is less than 3 hours away, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store Acabrunat 100 Capsule capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check your capsules: Inspect your capsule before taking it. Do not use any capsule that is broken, cracked, or leaking.
  • Watch for bleeding: This medication can make you bleed or bruise more easily. Avoid activities that carry a high risk of physical injury or cuts.
  • Inform all healthcare providers: Tell any dentist, surgeon, or specialist that you are taking Acabrunat 100 Capsule , as you may need to temporarily stop taking it before undergoing surgeries or dental procedures.
  • Monitor your heart rate: Keep track of your pulse. If you feel your heart racing, skipping a beat, or fluttering, report this to your doctor immediately.
  • Do not share your medicine: This is a highly specialised cancer medication. Never share it with anyone else, even if they have similar symptoms.

Drug-Drug Interactions

verifiedApollotooltip
  • Stomach acid reducers (Proton Pump Inhibitors): Taking drugs like omeprazole can significantly reduce how much Acabrunat 100 Capsule your body absorbs. Avoid taking PPIs while on this medication.
  • Blood thinners (Anticoagulants/Antiplatelets): Medicines like warfarin, aspirin, or clopidogrel can increase your risk of severe bleeding when taken with Acabrunat 100 Capsule .
  • Strong CYP3A inhibitors or inducers: Drugs like ketoconazole, clarithromycin, or rifampin can dramatically alter the levels of Acabrunat 100 Capsule in your blood, increasing side effects or reducing efficacy.
AcalabrutinibDasatinib
Severe
AcalabrutinibItraconazole
Severe

Drug-Drug Interactions

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AcalabrutinibDasatinib
Severe
How does the drug interact with Acabrunat 100 Capsule:
Using dasatinib together with Acabrunat 100 Capsule may increase the risk of bleeding.

How to manage the interaction:
Although taking Dasatinib and Acabrunat 100 Capsule together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - like difficulty with blood clotting, bleeding, complications, bruising, feeling dizzy or lightheaded, having red or black stools, coughing up blood, experiencing severe headaches, weakness, or vomiting - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
AcalabrutinibItraconazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Acabrunat 100 Capsule blood levels may be significantly raised by combining itraconazole and Acabrunat 100 Capsule.

How to manage the interaction:
Although there is a possible interaction between Acabrunat 100 Capsule and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
AcalabrutinibPiroxicam
Severe
How does the drug interact with Acabrunat 100 Capsule:
Using Acabrunat 100 Capsule together with piroxicam may increase the risk of bleeding.

How to manage the interaction:
Although taking Piroxicam and Acabrunat 100 Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
AcalabrutinibEsomeprazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Esomeprazole may interfere with the absorption of Acabrunat 100 Capsule and reduce their efficacy.

How to manage the interaction:
Taking Esomeprazole with Acabrunat 100 Capsule together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
AcalabrutinibPosaconazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Acabrunat 100 Capsule with posaconazole can considerably raise Acabrunat 100 Capsule levels in the blood. This may increase the side effects such as infections, abnormal heart rhythm, and bleeding.

How to manage the interaction:
Although using posaconazole and Acabrunat 100 Capsule together can result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor if you experience dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.
AcalabrutinibFosaprepitant
Severe
How does the drug interact with Acabrunat 100 Capsule:
Coadministration of Fosaprepitant with Acabrunat 100 Capsule can reduce the metabolism and increase the levels of Acabrunat 100 Capsule in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepitant with Acabrunat 100 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcalabrutinibLansoprazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Co-administration of Acabrunat 100 Capsule with Lansoprazole may reduce the effectiveness of Acabrunat 100 Capsule.

How to manage the interaction:
Although there is a possible interaction between Lansoprazole and Acabrunat 100 Capsule, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
AcalabrutinibCiprofloxacin
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Ciprofloxacin with Acabrunat 100 Capsule may increase your risk of acquiring irregular heart rhythm, anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Ciprofloxacin with Acabrunat 100 Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience paleness, exhaustion, dizziness, fainting, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, pain in the muscles, breathing difficulty, blood in the phlegm, weight loss, red or irritated skin, body sores, and discomfort or burning when urinating, consult the doctor.
AcalabrutinibApixaban
Severe
How does the drug interact with Acabrunat 100 Capsule:
Coadministration of Acabrunat 100 Capsule and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Acabrunat 100 Capsule and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AcalabrutinibRabeprazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Rabeprazole together with Acabrunat 100 Capsule results in a decreased effectiveness of Acabrunat 100 Capsule.

How to manage the interaction:
Although taking Rabeprazole and Acabrunat 100 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Seville oranges: These can interfere with the enzymes that break down Acabrunat 100 Capsule , leading to dangerously high levels of the drug in your body.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Acabrunat 100 Capsule is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL).
Acabrunat 100 Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.
You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.
Acabrunat 100 Capsule may cause nausea as a side effect. If you experience nausea, you can manage it by drinking plenty of clear liquids like water, fruit juices, or flat soda to prevent dehydration. Eat smaller, more frequent meals of bland foods that are easy to digest, like crackers, toast, or bananas. Avoid greasy, fried, sweet, or spicy foods. However, consult your doctor if nausea persists or worsens.
To relieve diarrhoea caused by Acabrunat 100 Capsule , stay hydrated by drinking plenty of water and clear fluids. Follow a bland diet of bananas, rice, applesauce, and toast. Avoid spicy, fatty, or high-fiber foods that can make diarrhoea worse. Talk to the doctor if you experience severe diarrhoea.
Avoid eating grapefruit and drinking grapefruit juice while taking Acabrunat 100 Capsule , as it may interact with the medication. Limit intake of alcohol as it may increase the risk of bleeding.
Consult the doctor if you notice changes in your skin like rash, light bruising, and small red or purple spots on your skin after taking Acabrunat 100 Capsule .
Acabrunat 100 Capsule may cause bleeding gums due to reduced platelets. Try gentle brushing with a soft-bristled toothbrush. If the issue persists, consult your doctor for appropriate treatment.
After starting treatment with Acabrunat 100 Capsule , you may feel tired or weak. To cope with this, prioritize rest and pace yourself. Take breaks, nap if needed, and engage in gentle exercises like yoga or short walks. Stay hydrated, eat small, frequent meals, and avoid heavy lifting or strenuous activities.
The doctor may advise regular blood tests before and during the treatment with Acabrunat 100 Capsule to check blood count. Additionally, liver and kidney function tests may also be recommended by the doctor.
The common side effects of Acabrunat 100 Capsule include anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.
Yes, you can take Acabrunat 100 Capsule with or without food. However, try to take it at the same time each day to maintain consistent levels of the medicine in your body. Talk to your doctor or pharmacist if you experience stomach upset.
You must inform your surgeon or dentist that you are taking Acabrunat 100 Capsule . Because this medicine can increase the risk of bleeding, you may need to stop taking it for a few days before and after your procedure. Always talk to your doctor before stopping your medication.
Some heartburn medicines, specifically proton pump inhibitors (PPIs), should be avoided because they lower stomach acid and reduce the absorption of Acabrunat 100 Capsule . H2-blockers or antacids may be used if timed carefully. Talk to your doctor or pharmacist for a safe schedule.
Hair loss is not a commonly reported side effect of Acabrunat 100 Capsule . Unlike traditional chemotherapy, this is a targeted therapy, meaning it is less likely to cause widespread hair loss. If you notice unusual hair thinning, talk to your doctor.
There is no direct, major interaction between Acabrunat 100 Capsule and alcohol, but drinking alcohol can worsen side effects like headaches, dizziness, or dehydration. It is best to limit your alcohol intake and talk to your doctor about what is safe for you.
No, Acabrunat 100 Capsule can cause harm to an unborn baby and should not be taken during pregnancy. You should also avoid breastfeeding while taking this medicine and for at least two weeks after your final dose. Talk to your doctor about highly effective birth control methods during your treatment.
In some patients, Acabrunat 100 Capsule can cause or worsen high blood pressure. Your doctor will likely monitor your blood pressure regularly during your treatment. Talk to your doctor if you experience unusually high blood pressure readings.

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Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - ACA0043
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