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compositionComposition:ABCIXIMAB-2MG
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Prescription Medicine
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ABCIXIREL 10MG INJECTION is used to prevent the formation of blood clots, thereby reducing the chance of Myocardial infarction. ABCIXIREL 10MG INJECTION contains Abciximab, which works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST). This medicine is always administered along with aspirin and heparin.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ABCIXIMAB-2MG

Manufacturer/Marketer :

Reliance Life Sciences

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ABCIXIREL 10MG INJECTION

ABCIXIREL 10MG INJECTION is a specialised prescription injection given during coronary artery procedures, such as angioplasty, to prevent blood clots from blocking blood flow in the heart. It is used in hospital settings to significantly lower the risk of a heart attack during or shortly after these heart interventions. This medical support is critical for maintaining healthy blood circulation when your blood vessels are being treated.

Because this medicine is given as a single-use treatment by a healthcare provider during a heart procedure, there is no daily dosing schedule for you to follow. It is injected directly into a vein, meaning food intake does not affect how it works. To support your heart's recovery, doctors highly recommend adopting a low-sodium, heart-healthy diet and avoiding strenuous physical activities immediately after your procedure.

The most common side effect is bleeding, which can occur at the injection site or internally. You should seek immediate medical attention if you notice severe bruising, blood in your urine, or sudden, unexplained weakness. Your healthcare team will monitor you closely during treatment to catch and manage any such issues early.

Before you receive this medicine, tell your doctor if you have a history of internal bleeding, recent major surgery, or severe uncontrolled high blood pressure, as you should not take this medicine under these conditions. It is also important to discuss any history of kidney disease or liver damage, as these conditions may affect how your body handles the treatment.

This medicine can interact with other blood thinners and certain pain relievers, which can increase your risk of bleeding. If you are pregnant, breastfeeding, or over the age of 65, consult your doctor to fully evaluate the risks and benefits before undergoing the procedure.

Uses of ABCIXIREL 10MG INJECTION

ABCIXIREL 10MG INJECTION is used to lower the risk of a heart attack during or shortly after these heart interventions. The detailed uses of ABCIXIREL 10MG INJECTION are as follows:

  • Preventing heart complications during coronary procedures: ABCIXIREL 10MG INJECTION helps prevent blood clots from forming in the arteries of the heart while a surgeon performs an angioplasty or other heart vessel clearing procedures.
  • Reducing the risk of a heart attack: By keeping blood vessels open, ABCIXIREL 10MG INJECTION lowers the chance of a heart attack or the need for an emergency repeat procedure in patients with unstable chest pain.

Key Benefits

ABCIXIREL 10MG INJECTION helps prevent blood clot formation during and after certain heart procedures, ensuring smooth blood flow through the coronary arteries. When used under medical supervision, it supports a safer recovery and reduces the risk of procedure-related complications.

  • Prevents Blood Clot Formation: By reducing the formation of blood clots, this medicine helps keep treated coronary arteries open, allowing the heart muscle to receive an adequate supply of oxygen-rich blood.
  • Supports Recovery After Heart Procedures: This medicine helps reduce the risk of sudden artery blockage following procedures such as coronary interventions, promoting a safer and more stable recovery.
  • Reduces the Risk of Cardiovascular Complications: By helping maintain normal blood flow, this medicine lowers the likelihood of clot-related complications and the need for emergency repeat procedures, supporting better overall treatment outcomes.
Side effects of Abcixirel 10mg Injection 5ml
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • ABCIXIREL 10MG INJECTION will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How ABCIXIREL 10MG INJECTION Works

ABCIXIREL 10MG INJECTION contains abciximab, which belongs to a group of medicines known as platelet aggregation inhibitors. Platelets are tiny blood cells that stick together to form clots when a blood vessel is injured. While clotting is normal to stop bleeding, it can be dangerous during a heart procedure if clots block blood flow to the heart. This medicine works by binding to specific receptors on the surface of your platelets, blocking the chemical signals that tell them to stick to one another. By preventing this clumping action, the medicine ensures that blood continues to flow freely through the treated heart vessels, significantly reducing the risk of a blockage.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption. Consult your doctor for more information.

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Pregnancy

Caution

It is also unknown whether ABCIXIREL 10MG INJECTION can cause fetal damage or alter reproductive capacity when given to a pregnant woman. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Caution

Limited data are available on the effect of ABCIXIREL 10MG INJECTION on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving ABCIXIREL 10MG INJECTION. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

ABCIXIREL 10MG INJECTION is used in PCI procedures in a hospital setting. Driving is not recommended.

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Liver

Caution

If you have liver problems, inform your doctor beforehand.

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Kidney

Unsafe

If you have kidney impairment, inform your doctor beforehand.

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Children

Unsafe

ABCIXIREL 10MG INJECTION is not recommended for use in children below 12 years of age, as efficacy and safety have not been established.

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Heart

Caution

ABCIXIREL 10MG INJECTION is often used in heart patients during procedures like angioplasty to prevent clots. It requires caution in those with bleeding risks or severe hypertension and is given under close medical supervision.

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Geriatrics

Caution

Geriatric patients can receive ABCIXIREL 10MG INJECTION, especially during heart procedures like angioplasty. However, it may have a higher risk of bleeding and should be closely monitored during treatment.

What if I have taken an overdose of ABCIXIREL 10MG INJECTION

Since ABCIXIREL 10MG INJECTION is administered under strict medical supervision in a hospital, an overdose is extremely rare. However, if too much medicine is given, it can increase the risk of bleeding. Your medical team is trained to recognise this immediately and can stop the infusion or give treatments to help stop any bleeding.

Diet & Lifestyle Advise

  • Limit high-impact activities: In the days following your procedure, avoid heavy lifting or high-impact activities that could cause injury, bruising, or bleeding.
  • Use a soft-bristled toothbrush: To protect your gums from bleeding while the medicine is still active in your system, use a soft toothbrush and avoid hard flossing.
  • Shave with care: Use an electric razor instead of a traditional blade to lower the risk of cutting your skin.
  • Eat a heart-healthy diet: Focus on a diet rich in fruits, vegetables, whole grains, and lean proteins to support long-term heart health after your coronary procedure.
  • Stay hydrated: Drink plenty of water as advised by your doctor to help your body recover and support healthy blood circulation.
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How Soon It Starts Working

The time required for ABCIXIREL 10MG INJECTION to start to work: ABCIXIREL 10MG INJECTION shows its action within 10 minutes of administration. The time for which the effects of ABCIXIREL 10MG INJECTION last: The duration of ABCIXIREL 10MG INJECTION effect is unknown.

What if you forget to take ABCIXIREL 10MG INJECTION

Because this medicine is given only by healthcare professionals during a scheduled hospital procedure, it is highly unlikely that you will miss a dose. If your procedure is delayed, your healthcare team will adjust the administration time accordingly.

Storage

•ABCIXIREL 10MG INJECTION is stored in a hospital or clinic setting. It must be kept in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the vial: Healthcare providers must inspect the solution before injection; do not use if it contains visible particles or is discoloured.
  • Avoid unnecessary injections: While receiving this medicine, other needle sticks or injections should be minimised to reduce the risk of bleeding at the puncture site.
  • Monitor the insertion site: Check the catheter insertion site frequently for redness, swelling, or active bleeding during and after the infusion.
  • Tell all healthcare providers: Make sure any dentist or other doctor you see shortly after your procedure knows that you received ABCIXIREL 10MG INJECTION.
  • Avoid aspirin unless directed: Do not take any over-the-counter pain relievers like aspirin or ibuprofen unless your cardiologist specifically instructs you to do so.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinners and Antiplatelet Medicines: Combining ABCIXIREL 10MG INJECTION with blood thinners, such as warfarin or heparin, or antiplatelet medicines can significantly increase the risk of serious bleeding. Your doctor will carefully assess the benefits and risks before using these medicines together.
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Pain relievers such as ibuprofen or naproxen may further increase the risk of bleeding when used around the time of treatment with ABCIXIREL 10MG INJECTION. Inform your doctor if you are taking any NSAIDs before your procedure.
AbciximabDeferasirox
Severe
AbciximabWarfarin
Severe

Drug-Drug Interactions

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AbciximabDeferasirox
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Using deferasirox together with Abcixirel 10mg Injection 5ml may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Abcixirel 10mg Injection 5ml with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
AbciximabWarfarin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of Warfarin with Abcixirel 10mg Injection 5ml can increase the effect of Warfarin.

How to manage the interaction:
Although there is a possible interaction between Warfarin and Abcixirel 10mg Injection 5ml, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor. Do not discontinue any medications without a doctor's advice.
AbciximabDabigatran etexilate
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Taking Dabigatran etexilate with Abcixirel 10mg Injection 5ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Abcixirel 10mg Injection 5ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AbciximabDasatinib
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Using Dasatinib together with Abcixirel 10mg Injection 5ml may increase the risk of bleeding.

How to manage the interaction:
Taking Abcixirel 10mg Injection 5ml with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away - bruising, feeling dizzy or lightheaded, dark stools, intense headaches. Do not stop using any medications without talking to a doctor.
AbciximabApixaban
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of Abcixirel 10mg Injection 5ml and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Abcixirel 10mg Injection 5ml and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AbciximabProtamine
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of protamine and Abcixirel 10mg Injection 5ml can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Protamine with Abcixirel 10mg Injection 5ml can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
AbciximabFondaparinux
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Taking Abcixirel 10mg Injection 5ml with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Abcixirel 10mg Injection 5ml and Fondaparinux, it can be taken if prescribed by a doctor. However, if you experience bleeding, bruising, feeling dizzy or lightheaded, dark or black stools, severe headache, weakness, bleeding, or vomiting contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AbciximabDalteparin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
The combined use of Abcixirel 10mg Injection 5ml with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Taking Abcixirel 10mg Injection 5ml with Dalteparin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bleeding, severe bleeding, bruising, dark or black stools, severe headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.
AbciximabClopidogrel
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of Clopidogrel with Abcixirel 10mg Injection 5ml it increases the risk of bleeding.

How to manage the interaction:
Although there is a interaction between clopidogrel and Abcixirel 10mg Injection 5ml, but it can be taken if prescribed by a doctor. However, consult your doctor immediately if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, and weakness. Do not discontinue any medications without consulting your doctor.
AbciximabHeparin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Taking Abcixirel 10mg Injection 5ml with Heparin may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Abcixirel 10mg Injection 5ml with Heparin can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - bleeding, bruising, vomiting, headache, dizziness, weakness, or blood in your urine or stools, it's important to contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known significant food interactions with ABCIXIREL 10MG INJECTION when used as directed. Follow your doctor's instructions regarding food and fluid intake before and after your procedure.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

ABCIXIREL 10MG INJECTION is used to treat Myocardial infarction (heart attack).
ABCIXIREL 10MG INJECTION contains Abciximab, which works by blocking the activity of glycoprotein IIb/IIIa receptor and thereby prevents platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation.
ABCIXIREL 10MG INJECTION may cause anaemia (low haemoglobin and low red blood cell count). So, it would be best to include iron-rich food in your diet to prevent anaemia.
While taking ABCIXIREL 10MG INJECTION, avoid medicines like painkillers (aspirin, ibuprofen, celecoxib, hydrocodone, tramadol), blood thinners (clopidogrel, dalteparin, enoxaparin, rivaroxaban, prasugrel, warfarin, heparin), ACE inhibitors (captopril, enalapril), calcium channel blockers (nifedipine, cilnidipine), and beta-blockers (atenolol, sotalol) due to potential interactions. Therefore, always consult your doctor before using ABCIXIREL 10MG INJECTION with other medicines.
You may begin to feel better within a few hours to a day after receiving ABCIXIREL 10MG INJECTION, as it acts quickly to prevent blood clots. However, complete improvement could take a couple of days, based on your condition. If you have any concerns regarding this, please discuss with your doctor.
ABCIXIREL 10MG INJECTION causes side effects such as bleeding, nausea, headache, abdominal pain, hypotension, vomiting, dizziness, back pain, and pain at the site of injection. However, contact a doctor if these side effect persists longer.
ABCIXIREL 10MG INJECTION is given through an intravenous (IV) line in your vein. It starts with a quick injection (bolus) followed by a continuous, slow drip (infusion) that lasts for several hours during and after your heart procedure. Talk to your doctor if you have questions about this process.
Yes. ABCIXIREL 10MG INJECTION reduces the ability of platelets to form blood clots, so it can increase the risk of bleeding and bruising, especially when used together with medicines such as heparin or aspirin. Your healthcare team will monitor you closely during treatment. Contact your doctor immediately if you notice unusual or excessive bleeding, black stools, blood in the urine, or prolonged bleeding from cuts.
ABCIXIREL 10MG INJECTION is generally only used during pregnancy if the potential benefit justifies the risk to the baby. If you are pregnant or planning to become pregnant, talk to your doctor to discuss your treatment options.
No, because ABCIXIREL 10MG INJECTION is given during a coronary procedure, you will need to stay in the hospital for observation. Your medical team will monitor your recovery and check for any signs of bleeding before you are safely discharged. Talk to your doctor about your recovery timeline.
You should avoid activities that could cause physical injury, such as contact sports or heavy lifting, for a period recommended by your doctor. You should also avoid taking over-the-counter pain relievers like ibuprofen unless approved by your healthcare team. Talk to your doctor or pharmacist for a complete list of what to avoid.
Yes, but your doctor will need to evaluate your kidney function closely. In some cases, adjustments to other medications used during the procedure may be necessary. Talk to your doctor if you have kidney concerns.
No, ABCIXIREL 10MG INJECTION is not a long-term medicine. It is only given as a short-term, one-time treatment during and immediately after a coronary procedure to prevent acute clotting. Talk to your doctor about the long-term medicines you will need to take at home.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Dhirubhai Ambani Life Sciences Centre, R-282, TTC Area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai 400 701
Other Info - ABC0025
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