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compositionComposition:CEFOPERAZONE-250MG
prescription
Prescription Medicine
info
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3 Cef 375 Injection is used to treat various bacterial infections such as respiratory tract (lungs) infection, urine infection, blood infection, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), skin, abdominal, bone, and joint infections. It contains Cefoperazone, which works by preventing the formation of bacterial cell covering necessary for their survival by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan and killing the bacteria. It may cause diarrhoea, allergic reactions, abnormal liver function tests, and anaemia (low number of red blood cells). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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More about the Product

Composition :

CEFOPERAZONE-250MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About 3 Cef 375 Injection

3 Cef 375 Injection is a prescription antibiotic injection used to treat a wide variety of severe bacterial infections. It works by targeting and killing the bacteria responsible for infections in the lungs, urinary tract, skin, and abdomen. Doctors typically prescribe this medication for hospitalised patients or those needing specialised medical care.

Because this medicine is injected directly into a vein or a muscle, it is usually given by a healthcare provider at regular intervals to maintain steady levels in your body. To help your body recover more quickly, it is important to stay well-hydrated, get plenty of rest, and eat a balanced diet rich in vitamins while receiving this treatment.

While using 3 Cef 375 Injection, some people may experience mild side effects such as diarrhoea, nausea, or pain at the injection site. However, you must contact your doctor immediately if you notice serious signs like severe watery diarrhoea, unusual bruising, yellowing of the skin or eyes, or a sudden allergic reaction.

Before starting treatment, let your doctor know if you have a history of liver disease, kidney problems, or bleeding disorders. Do not take this if you have a known severe allergy to cephalosporin antibiotics or penicillins.

You should avoid drinking alcohol while receiving 3 Cef 375 Injection and for several days after, as mixing them can cause severe nausea, sweating, and a rapid heartbeat. Always consult your healthcare provider if you are pregnant, breastfeeding, or managing health conditions as an elderly individual, as your dose may need careful monitoring.

Uses of 3 Cef 375 Injection

3 Cef 375 Injection is used to treat a wide variety of severe bacterial infections. The detailed uses of 3 Cef 375 Injection are as follows:

  • Severe lung infections: It targets and destroys the bacteria causing severe pneumonia and other deep chest infections.
  • Urinary tract infections: It treats complicated infections of the bladder and kidneys by clearing harmful bacteria from the urinary system.
  • Abdominal infections: It helps resolve serious infections inside the stomach area, such as peritonitis, by stopping bacterial growth.
  • Skin and soft tissue infections: It clears deep-seated bacterial infections of the skin, tissues, and surgical wounds.
  • Blood infections: It treats septicemia, a life-threatening bacterial infection in the bloodstream, by rapidly killing the invading bacteria.

Key Benefits

3 Cef 375 Injection helps treat serious bacterial infections by rapidly eliminating infection-causing bacteria. When administered as prescribed, it helps control severe infections, relieve symptoms, and support a faster recovery.

  • Treats Serious Bacterial Infections: Given by injection, this medicine delivers the antibiotic directly into the body, allowing it to act quickly against susceptible bacteria and support effective infection control.
  • Relieves Infection Symptoms: As the bacterial infection clears, this medicine helps reduce fever, pain, swelling, inflammation, and fatigue, improving comfort and promoting recovery.
  • Supports Faster Recovery: Early and effective treatment helps prevent the infection from worsening or spreading, shortens recovery time, and may reduce the length of hospital stay in patients requiring injectable antibiotic therapy.
Side effects of 3 Cef 375 Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • 3 Cef 375 Injection is administered by the doctor or nurse.
  • Do not self-administer.

How 3 Cef 375 Injection Works

3 Cef 375 Injection contains cefoperazone, which belongs to a group of medicines known as cephalosporin antibiotics. It works by interfering with the way bacteria build their protective outer walls. Bacteria need these walls to survive, multiply, and protect themselves from their environment. By blocking the chemical processes needed to construct these cell walls, 3 Cef 375 Injection creates weak spots in the bacterial defence. This causes the bacterial cells to rupture and die, effectively stopping the infection from spreading further and allowing your body's natural immune system to clear the remaining bacteria.
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Alcohol

Caution

Avoid consuming alcohol while taking 3 Cef 375 Injection as it causes increased side effects.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant, your doctor will prescribe 3 Cef 375 Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

A small amount of 3 Cef 375 Injection may pass into breast milk. Avoid taking 3 Cef 375 Injection if you are breastfeeding unless prescribed.

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Driving

Caution

3 Cef 375 Injection may cause dizziness in some people, so it may affect your ability to drive.

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Liver

Consult your doctor

Dose adjustment may be needed. Please consult your doctor before taking 3 Cef 375 Injection if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking 3 Cef 375 Injection.

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Children

Safe if prescribed

For children, 3 Cef 375 Injection is safe if prescribed by the doctor. Consult your doctor for more infoemation.

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Heart

Caution

If you have heart problems, 3 Cef 375 Injection can be used, but with caution and under close medical supervision.

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Geriatrics

Caution

Geriatric patients can generally receive 3 Cef 375 Injection, but with careful monitoring and dose adjustments may be needed.

What if I have taken an overdose of 3 Cef 375 Injection

If you suspect an overdose or experience severe muscle twitches, seizures, or extreme dizziness after an injection, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Hydration: Drink plenty of water throughout the day. Getting an injection for severe infections requires good hydration to help your kidneys flush out the medication's breakdown products safely.
  • Probiotic Support: Consider eating probiotic-rich foods like yoghurt or kefir, or taking a probiotic supplement a few hours after your injection. Strong antibiotics can disrupt your gut's natural bacterial balance, and probiotics help prevent antibiotic-associated diarrhoea.
  • Avoid Alcohol completely: Do not consume alcohol during your entire treatment course and for at least 72 hours after your final dose. This medicine can react with alcohol to cause severe flushing, headache, nausea, and rapid heartbeat.
  • Rest and Recovery: Allow your body plenty of rest. Fighting a severe systemic infection requires significant energy, and resting helps your immune system work more effectively alongside the medication.
  • Nutrient-Rich Diet: Focus on a diet high in lean proteins, vitamins, and minerals to assist in tissue repair and support your immune recovery.
health query

Have a query?

How Soon It Starts Working

The time required for 3 Cef 375 Injection to start to work: The onset of time for 3 Cef 375 Injection is clinically unknown. The time for which the effects of 3 Cef 375 Injection last: 3 Cef 375 Injection effects last for approximately 24 hours after administration.

What if you forget to take 3 Cef 375 Injection

If you receive this medicine in a clinic and miss an appointment, contact your healthcare provider immediately to reschedule. If you are injecting it at home and miss a dose, take it as soon as you remember. However, if it is almost time for your next injection, skip the missed dose and return to your regular schedule. Do not inject a double dose to make up for a missed one.

Storage

• Store the dry powder vials of 3 Cef 375 Injection at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the liquid closely before every injection; do not use it if you see floating particles, cloudiness, or any discolouration.
  • Always rotate your injection sites (e.g., different areas of your thigh, arm, or abdomen) to prevent skin irritation, pain, or hardening of the tissue.
  • Never reuse disposable needles, syringes, or vials, as this dramatically increases your risk of developing a serious skin or blood infection.
  • Tell your doctor immediately if you develop watery, severe diarrhoea, even if it starts weeks after your treatment with 3 Cef 375 Injection has finished.
  • If you are scheduled for any lab tests (such as urine glucose tests), inform the laboratory staff that you are using 3 Cef 375 Injection, as it can cause false-positive test results.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (such as warfarin): 3 Cef 375 Injection can increase the risk of bleeding by lowering your body's vitamin K levels.
  • Aminoglycoside antibiotics: Combining these medications may increase the risk of kidney damage. Your doctor may need to monitor your kidney function closely.
CefoperazoneBCG vaccine
Critical
CefoperazoneRifampicin
Severe

Drug-Drug Interactions

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CefoperazoneBCG vaccine
Critical
How does the drug interact with 3 Cef 375 Injection:
When BCG vaccine is used with 3 Cef 375 Injection, its effectiveness may be reduced.

How to manage the interaction:
Taking 3 Cef 375 Injection with BCG vaccine is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor
CefoperazoneRifampicin
Severe
How does the drug interact with 3 Cef 375 Injection:
Taking 3 Cef 375 Injection and Rifampicin together may increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between 3 Cef 375 Injection and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol or products containing alcohol (like certain cough syrups) while using 3 Cef 375 Injection can cause a severe disulfiram-like reaction, leading to flushing, headache, rapid breathing, and vomiting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

3 Cef 375 Injection is used to treat various bacterial infections, such as respiratory tract (lungs) infections, urine infections, blood infections, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), and skin, abdominal, bone, and joint infections.
3 Cef 375 Injection is an antibiotic that contains Cefoperazone (cephalosporin antibiotic). 3 Cef 375 Injection works by preventing the formation of bacterial cell covering, which is necessary for their survival by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan and kills the bacteria. Thereby, 3 Cef 375 Injection helps to treat bacterial infections.
Inform your doctor if you do not feel better even after finishing the full course of treatment. You must also inform your doctor if the symptoms get worse while using this medicine.
Usually, 3 Cef 375 Injection starts working soon after taking it. It may take a few days to kill all the dangerous bacteria and make you feel better.
3 Cef 375 Injection may cause Clostridium difficile-associated diarrhoea (CDAD). Treatment with antibiotics alters the normal flora, leading to overgrowth of Clostridium difficile; this causes diarrhoea. Drink lots of fluids and eat fibre-rich food if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking 3 Cef 375 Injection and consult your doctor. Do not take anti-diarrhoeal medicine on your own.
As 3 Cef 375 Injection is administered in a hospital by a healthcare provider, Therefore, the chances of missing a dose is less. However, if you have any concerns, contact your doctor. Do not self-administer.
Common side effects of 3 Cef 375 Injection include diarrhoea, allergic reactions, abnormal liver function tests, and anemia. Most of these side effects are temporary and resolve on their own. However, if they persist, consult your doctor for proper evaluation and guidance.
No, you must avoid alcohol completely during your treatment and for at least three days after your last dose. Combining this medicine with alcohol can cause a severe reaction with symptoms like intense flushing, nausea, vomiting, headache, and a fast heartbeat. Talk to your doctor if you have questions about this.
This medicine is given parenterally, meaning it is injected either directly into a vein as an infusion or into a large muscle. A healthcare professional typically gives these injections in a clinical setting, though some patients may be trained to do it at home. Talk to your doctor for specific guidance on your treatment.
If you have a history of mild penicillin allergy, you may still be able to use this medicine, but you must exercise caution. If you have had a severe, life-threatening allergic reaction to penicillin, do not use this medicine. Always talk to your doctor about your complete allergy history before starting treatment.
Mild pain, redness, or swelling at the injection site is a common reaction. To help manage this, make sure to rotate your injection sites for each dose. If the pain worsens, or if you notice spreading redness, warmth, or pus, talk to your doctor or pharmacist right away.
This medicine should only be used during pregnancy or breastfeeding if it is clearly needed and prescribed by your healthcare provider. Your doctor will weigh the benefits of clearing the infection against any potential risks to the baby. Talk to your doctor if you are pregnant or planning to breastfeed.
Stopping your antibiotic treatment early can allow the strongest bacteria to survive, multiply, and become resistant to treatment. This means your infection could return and be much harder to treat. Always complete the full course exactly as prescribed, and talk to your doctor if you feel unable to continue.
Yes, this medicine can interfere with certain lab tests, particularly urine glucose tests used by diabetic patients, causing false-positive results. Always inform your laboratory technician and healthcare team that you are receiving this injection before undergoing any tests. Talk to your doctor for alternative testing methods if needed.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - 3CE0005
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