Treating a diabetic foot wound depends on the infection's severity. For mild infections, oral antibiotics like cephalexin, clindamycin, or amoxicillin-clavulanate are commonly prescribed. For moderate to severe infections, broader-spectrum antibiotics such as piperacillin-tazobactam, levofloxacin, or vancomycin may be used. Because these infections can involve multiple types of bacteria, doctors usually select the exact antibiotic based on a wound culture. It is highly recommended to have a healthcare professional evaluate the wound to prescribe the safest, most effective targeted therapy for proper healing.