Dermatosis Papulosa Nigra (DPN) is a completely harmless, benign skin condition. For removal, in-office dermatological procedures are highly effective. These include electrodessication (using a minor electric current to dry them out), curettage (scraping), cryotherapy (freezing), or laser therapy. Topical creams, including prescription retinoids, cannot easily remove these raised bumps but can improve overall skin texture. Because DPN is largely genetic, there is no guaranteed way to prevent new ones from forming. However, protecting your skin daily with a broad-spectrum sunscreen (SPF 30 or higher) is the best way to help prevent existing spots from darkening or multiplying.