Isotretinoin frequently results in dryness inside the nose, which can cause irritation, crusting, moderate bleeding, and congestion at night. This occurs as a result of the medication's reduction of moisture and oil in the nasal lining. The dryness may be relieved by using a saline nasal spray, inhaling steam, drinking plenty of water, and putting a tiny bit of saline gel or simple petroleum jelly inside the nostrils. Don't use decongestant nasal sprays excessively. It is best to go to your dermatologist or ENT physician about this since you have been experiencing symptoms for five months. The dose may need to be changed, and the nose may need to be examined.

Acne marks often take time to fade, even after the acne is controlled. While lotions containing azelaic acid may help reduce pigmentation and improve skin texture, your skin may be more sensitive because you are taking isotretinoin. Using additional active products without guidance may cause irritation. Consult your doctor before using any new lotion as part of your treatment.