Joint, bone, and muscle pain can occur in some people taking imatinib for a long time because the medicine may affect muscles, fluid balance, mineral levels, and connective tissues over time. Fatigue, cramps, stiffness, swelling around the joints, and body aches are also reported by some patients during long-term treatment. Since you have been using Imatinib 400 mg for many years, these symptoms may need proper assessment rather than ignoring them as simple ageing-related pain. Management usually focuses on checking for contributing factors such as calcium or vitamin D deficiency, anaemia, muscle inflammation, electrolyte imbalance, or arthritis. Gentle stretching, physiotherapy, adequate hydration, regular movement, and maintaining protein intake may help reduce stiffness and improve mobility. Doctors may sometimes recommend pain-relieving medicines, calcium or vitamin supplements, or adjustment of supportive treatment depending on test results and symptom severity. Sudden severe swelling, breathing difficulty, chest pain, marked weakness, or worsening bone pain should be evaluated carefully during ongoing cancer treatment.