Nighttime pain in your second toe can have a few common and manageable causes. It could be due to joint inflammation (capsulitis), minor nerve irritation, mild osteoarthritis, or occasionally gout. To help relieve the discomfort, you can try over-the-counter pain relievers such as ibuprofen or acetaminophen, which help reduce both pain and inflammation. Elevating your foot or applying a cold compress before bed may also help. Since proper treatment depends on the exact cause, I highly recommend scheduling a brief visit with a healthcare professional or podiatrist for an accurate diagnosis. Rest assured, these issues are very common and highly treatable.