To help relieve your mother?s nighttime leg pain, her doctor may suggest venotonic medications like Micronised Purified Flavonoid Fraction (MPFF), which improve blood circulation and reduce vein swelling. For immediate pain relief, over-the-counter Acetaminophen (Paracetamol) can be helpful. Non-medicinal practices are also crucial: elevating her legs above heart level using pillows at night, wearing prescribed compression stockings during the day, and performing light leg stretches before bed. Please consult her physician or a vascular specialist for an accurate diagnosis and a tailored prescription before starting any new medication.