Both topical tretinoin and benzoyl peroxide are highly effective, but they target acne differently. Tretinoin is excellent for unclogging pores, preventing blackheads, and promoting skin renewal, making it ideal for long-term prevention. Benzoyl peroxide is an antibacterial agent that quickly targets and reduces active, inflamed pimples. Neither is strictly 'better' as they complement each other. In fact, dermatologists often recommend using both benzoyl peroxide in the morning to fight bacteria and tretinoin at night to clear pores. Since both can cause mild dryness initially, please consult a healthcare provider to find the safest routine for your skin.