Years after a severe stroke, there is no single medication to fully restore these functions, but some options can support recovery alongside therapy. Doctors sometimes trial medications like amantadine, levodopa, or methylphenidate to help improve alertness, speech initiation, and motor function. If muscle stiffness (spasticity) is limiting movement or causing discomfort, muscle relaxants like baclofen or targeted botulinum toxin injections can help relax the muscles. Additionally, certain SSRIs like fluoxetine are sometimes prescribed to support brain plasticity. Please consult a neurologist to discuss if any of these targeted therapies are safe and appropriate for your loved one's specific condition.