Yes, AKT- 2 tablets (Rifampicin and Isoniazid) may sometimes cause allergic reactions in some people. The skin rashes and hives you are experiencing may be a sign that your body is reacting to the medicine. This should not be ignored, as medicines used for tuberculosis are strong and need careful monitoring. It is important to contact your doctor as soon as possible and tell them about your symptoms. Do not stop the tablets on your own, because stopping treatment suddenly can make tuberculosis harder to control and may affect your recovery. Your doctor will examine you and decide whether the medicine needs to be changed or adjusted.d. For now, try not to scratch the itchy areas, as this may worsen the rash or lead to infection. Keep your skin cool, wear loose cotton clothes, and avoid hot baths or showers. Your doctor may also prescribe an antihistamine medicine to reduce itching or recommend a soothing lotion. If you notice swelling of the face or lips, or have difficulty breathing, seek emergency care immediately, as these may indicate a severe allergic reaction.