Your pain, especially when pressing the center of your abdomen on an empty stomach, suggests conditions like gastritis, a peptic ulcer, or acid reflux. Since the ofloxacin-ornidazole combination and antacid haven't provided relief, the cause might be non-infectious, or requires a different approach. Please consult your doctor to discuss: 1. Alternative medications: Upgrading to a stronger acid-suppressor (like pantoprazole or rabeprazole) or adding a mucosal protector (like sucralfate). 2. Diagnostic tests: An abdominal ultrasound or an endoscopy to pinpoint the cause, such as gallstones or H. pylori. Rest assured, these issues are very common and highly treatable with the right diagnosis.