It is very common to have a weakened immune system for a year or more after a transplant. For prevention, your transplant team may prescribe daily prophylactic medications. These typically include antivirals like acyclovir to prevent viral shingles, and sometimes preventative antibiotics. Staying updated on your post-transplant vaccine schedule is also crucial. For treating active infections, there is no single over-the-counter option. Because your immune system is still recovering, you must contact your transplant team immediately if you develop a fever or symptoms of infection. They will prescribe the appropriate, targeted antibiotics or antivirals. Avoid self-medicating to ensure your safety.